VCRC Tissue Repository

University of Pennsylvania

Status: Enrolling

Conditions: Giant Cell Arteritis; Eosinophilic Granulomatosis With Polyangiitis; Cutaneous Vasculitis; Polyarteritis Nodosa; Granulomatosis With Polyangiitis (Wegener's); Henoch-Schonlein Purpura; Takayasu Arteritis; Microscopic Polyangiitis; Aortitis; Churg-Strauss Syndrome; IgA Vasculitis

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT02967068

VCRC5511

U54AR057319 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

The purpose of this study is to collect existing tissue specimens from subjects enrolled in Vasculitis Clinical Research Consortium (VCRC) studies. Analysis of these tissue specimens and linked clinical data collected through VCRC studies may lead to the identification and development of a series of translational research projects. Results of these studies will provide vasculitis researchers with insight into the causes of these diseases and generate new ideas for diagnostic tests and therapies, and will be of great interest to the larger communities of researchers investigating vasculitis and other autoimmune, inflammatory, and vascular diseases.

Full description

Biopsy specimens collected as standard of care for these diseases will be retrieved and used in research. The most common biopsies performed are kidney, lung, skin, nerves, and vessels; however, other tissue is also of interest for the study. Biopsies are not performed as part of this protocol, rather we will request consent to collect biopsy specimens already collected under routine care.

Enrollment: 1,000 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• A participant will be deemed eligible for this study if the participant is/was enrolled in another one of the VCRC observational/longitudinal protocols (5502, 5503, 5504, 5505, 5506, 5507, 5563) and/or one of the VCRC interventional studies (5522, 5523, 5526, 5527, or 5562).

Exclusion criteria

• Inability to give informed consent (or their guardians in the case of children) and to sign the consent form.
• Unwilling to allow the use of their tissue for research.