VDR and TFIP11 Gene Polymorphism and Gene-environmental Interaction in Adults

Recep Tayyip Erdogan University Training and Research Hospital

Status: Completed

Conditions: Low Caries Experience; High Caries Experience

Treatments: Genetic: high caries experience

Study type: Observational

Funder types: Other

Identifiers

NCT04124718

2019-204

Details and patient eligibility

About

VDR and TFIP11 Gene polymorphism and gene-environment interactions on caries etiology and susceptibility in adults.

Full description

To date, genes can be grouped into categories based on the factor influencing dental caries. The major candidate gene categories to date include enamel formation genes, immune response genes, genes related to saliva, and genes related to taste and dietary habits.

TFIP11 and VDR genes are related to enamel formation genes

Enrollment: 160 patients

Sex: All

Ages: 24 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• adult be between 24 and 40 years old
• subject has DMFT (Decayed, Missing, Filled, Permanent Tooth) DMFT≤4 , or, DMFT>13.9

Exclusion criteria

• systemic or genetic disorders
• orthodontic appliances
• pregnant women

Trial design

160 participants in 2 patient groups

high caries experience

Description:

80 adults will be allowed in the high caries experience group according to DMFT index DMFT\>13.9

Treatment:

Genetic: high caries experience

low caries experience

Description:

80 adults will be allowed in the high caries experience group according toDMFT index DMFT≤4

Treatment:

Genetic: high caries experience