Vecuronium Requirements According to the Operation Phase During Liver Transplantation Under Desflurane Anesthesia

Samsung Medical Center

Status: Completed

Conditions: Liver Transplantation

Study type: Observational

Funder types: Other

Identifiers

NCT01379352

2011-04-015

Details and patient eligibility

About

The vecuronium requirements may be reduced for recipients of living donor liver transplantation, as the vecuronium is eliminated principally by the liver. Furthermore, the requirements may be different according to the phase of surgery. The requirements may also be different according to the preoperative hepatic function as measured by MELD score during prehepatic phase, or graft to recipient body weight ratio (GRWR) during neohepatic phase. Therefore, the investigators are trying to investigate the difference of vecuronium requirements according to the phase of surgery or MELD score, GRWR.

Full description

The vecuronium requirements may be reduced for recipients of living donor liver transplantation, as the vecuronium is eliminated principally by the liver. Furthermore, the requirements may be different according to the phase of surgery. The requirements may by further reduced during anhepatic phase of liver transplantation. And the requirements may be increased as the graft functions during neohepatic phase.

We also postulated that the requirements may be different according to the preoperative hepatic function during preanhepatic phase, and according to the graft to recipient body weight ratio (GRWR) during neohepatic phase.

Therefore, we are trying to investigate the difference of vecuronium requirements according to the phase of surgery, MELD score, GRWR.

Enrollment: 35 patients

Sex: All

Ages: 20 to 69 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients undergoing elective living donor liver transplantation

Exclusion criteria

• patients who can not undergo train-of-four test due to central or peripheral neuromuscular disease.
• patients with severe cardiopulmonary diseases.
• patients who received transfusion with more than 10 units of packed red blood cells.
• primary non-functioning graft immediately after reperfusion of the graft.
• patients who administered drugs that influences the metabolism of vecuronium (such as anticonvulsant: phenytoin, carbamazepine, primidone, sodium valproate)
• patients undergoing cadaver donor liver transplantation

Trial design

35 participants in 2 patient groups

High MELD group

Description:

Preoperative MELD score greater than 20

Low MELD group

Description:

Preoperative MELD score lesser than 20