Vegan Diet, Amla Fruits and Uric Acid

Fu Jen Catholic University

Status: Completed

Conditions: Hyperuricemia; Cardiometabolic Syndrome; Diet, Healthy

Treatments: Other: Healthy vegan diet; Other: Amla fruits; Other: My Plate - Low Purine

Study type: Interventional

Funder types: Other

Identifiers

NCT04801745

Interventional (Other Identifier)

Details and patient eligibility

About

This is an intervention study aiming to test the effectiveness of a vegan diet, My Plate with low purine choices, and amla fruits on uric acid and other cardiometabolic risk factors in individuals with high serum uric acid levels.

Full description

Ninety-two participants with hyperuricemia will be randomly assigned to one of these 4 diet interventions: (1) vegan, (2) vegan with amla fruits, (3) my plate-low purine, (4) my plate-low purine with amla fruits. During the 3 months intervention phase, participants will attend group lessons and individual nutrition counseling sessions to assist adherence to the diet. At baseline, end of 3 months, and 1 year, participants will be measured on uric acid and other cardiometabolic risk factors, and some nutritional markers. Amla fruits powder, and some foods encouraged in each dietary arm will be provided to enhance adherence during the 3 months intervention phase.

Enrollment: 102 patients

Sex: All

Ages: 19+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Men with serum uric acid > 7mg/dL
• Women with serum uric acid > 6mg/dL
• Willing to make diet changes according to dietary interventions

Exclusion criteria

• Age <19
• With cancer diagnosis
• With diseases that require special dietary needs
• On urate-lowering medication within 3 months

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Factorial Assignment

Masking: None (Open label)

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102 participants in 4 patient groups

Healthy Vegan Diet

Experimental group

Description:

Education on healthy vegan diet

Treatment:

Other: Healthy vegan diet

Healthy Vegan Diet with Amla fruits

Experimental group

Description:

Education on healthy vegan diet, 3g of powdered amla fruits per day

Treatment:

Other: Amla fruits

Other: Healthy vegan diet

My Plate - Low Purine

Active Comparator group

Description:

Education on "My Plate" diet with emphasis on choosing low purine protein options.

Treatment:

Other: My Plate - Low Purine

My Plate - Low Purine with Amla Fruits.

Experimental group

Description:

Education on "My Plate" diet with emphasis on choosing low purine protein options and with an addition of 3g of amla powder per day.

Treatment:

Other: My Plate - Low Purine

Other: Amla fruits