Vegan vs AHA Diet on Inflammation and Glucometabolic Profile in Patients With CAD

NYU Langone Health

Status

Completed

Conditions

Coronary Artery Disease

Inflammation

Treatments

Behavioral: Diet

Study type

Interventional

Funder types

Other

Identifiers

NCT02135939

14-00292

Details and patient eligibility

About

In this randomized study the investigators aim to determine the effects of a whole-food plant-based vegan diet on markers of inflammation and glucometabolic profile in patients with cardiovascular disease. The investigators hypothesize that a whole-food plant-based vegan diet will reduce markers of inflammation and improve glucometabolic profile compared with the American Heart Association (AHA)- recommended diet at 2 months follow-up in patients with coronary artery disease (CAD). The investigators are also evaluating endothelial function using the EndoPAT device and stool microbiome.

Enrollment

100 patients

Sex

All

Ages

21+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Subjects on stable medical therapy for at least 7-10 days post-coronary angiography and found to have CAD (defined as >50% lesion in an artery with >2mm caliber) .

Exclusion criteria

Failure of the Treatment Self-Regulation Questionnaire
Use of steroids or non-steroidal anti-inflammatory medications other than aspirin
Use of probiotics or over the counter supplements other than standard vitamins
Have a history of myocardial infarction or active infection within the preceding 3 months
Have a history of an eating disorder or colon cleansing or are already on a whole-food plant-based vegan diet
Have a planned PCI during the study period
Are participating in a competing study
Have any condition or situation that, in the investigator's opinion, may confound the study results, or may interfere significantly with the patient's ability to adhere with study procedures