Vegetable Signature From Human Metabolomics Responses

National Health Research Institutes, Taiwan

Status: Completed

Conditions: Vegetable Signature Documentation With Metabolomic Technique

Treatments: Other: Celery; Other: Mixed Vegetables; Other: Spinach; Other: Control; Other: Onion

Study type: Interventional

Funder types: Other

Identifiers

NCT03483558

NHRI_EC0991003

Details and patient eligibility

About

The purpose of this study is to perform dietary intervention studies on a variety of vegetables.

Full description

Plant-based foods have always been an important component of a healthy diet. High intake of plant foods may not only maintain normal bodily functions through the provision of dietary fiber, vitamins, and minerals but also relieve symptoms and prevent diseases. Many studies have pointed out that high intake of plant foods may reduce the incidence of non-communicable disease. Past research investigating the effect of phytochemicals has usually been limited to single substances or single foods. However, a number of researchers have pointed out that phytonutrients and dietary components are likely to act synergistically.Health effects and mechanisms of phytonutrients in combination have not been carefully studied in population settings. The technology of metabolomics has enabled the simultaneous measurement of hundreds of small molecules in biological samples. Exploring the change of metabolites after feeding can not only help us understand the role of plant foods, but may also provide opportunities to assess plant food intake levels.

Enrollment: 13 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• BMI 18.5~30 kg/m2
• non-smoker
• non-alcoholic

Exclusion criteria

• Unwilling to stop taking the dietary supplements that may affect the experiment result.
• Unwilling to take the provided meal during the designated period.
• Taking hypertension or diabetes drugs.
• Diagnosed immune diseases (such as allergic diseases, autoimmune diseases, etc.), liver diseases, metabolic diseases (such as hyperthyroidism or hypothyroidism), or other not suitable for the dietary study.
• Diagnosed cancer or other severe diseases.
• Suffered from urinary tract infection or took antibiotic in the past three months

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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13 participants in 5 patient groups

Control

Experimental group

Description:

Participants were fed a standardized diet (without any vegetables) in this experiment.

Treatment:

Other: Control

Spinach

Experimental group

Description:

Participants were fed a standardized diet with 200g spinach in this experiment.

Treatment:

Other: Spinach

Celery

Experimental group

Description:

Participants were fed a standardized diet with 200g celery in this experiment.

Treatment:

Other: Celery

Onion

Experimental group

Description:

Participants were fed a standardized diet with 200g onion in this experiment.

Treatment:

Other: Onion

Mixed Vegetables

Experimental group

Description:

Participants were fed a standardized diet with 200g of mixed vegetables (spinach, celery, and onion) in this experiment.

Treatment:

Other: Mixed Vegetables