VEGF and PEDF in Patients With Myopic Choroidal Neovascularization

Università degli Studi di Brescia

Status: Completed

Conditions: VEGF Aqueous Level; Myopic Choroidal Neovascularization; PEDF Aqueous Level

Study type: Observational

Funder types: Other

Identifiers

NCT02175940

VEGF001

Details and patient eligibility

About

This was a prospective, case-control study investigating aqueous levels of VEGF and PEDF in eyes with mCNV treated with IVB.

Enrollment: 40 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• pathologic myopia, defined as spherical equivalent >6 diopters and axial length >26 mm
• posterior pole myopic retinal changes (posterior staphyloma, chorioretinal atrophy, papillary crescent);
• fluorescein angiography, indocyanine green angiography and optical coherence tomography detection of the subfoveal or juxtafoveal choroidal neovascularization
• clear ocular media;

Exclusion criteria

• previous treatment for choroidal neovascularization, including the previous intravitreal drug injection or PDT
• presence of other maculopathy as diabetic retinopathy or retinal vascular occlusion
• history of recent myocardial infarction or other thromboembolic events
• ongoing uncontrolled hypertension or glaucoma
• refractive media opacities
• previous eye surgery

Trial design

40 participants in 2 patient groups

Myopic Choroidal Neovascularization patients

Control patients undergoing cataract surgery