VEGF Gene Association With Response to Neovascular Age-related Macular Degeneration With Anti-VEGF Agents

Institute of Vision, Brasil

Status: Unknown

Conditions: Macular Degeneration

Study type: Observational

Funder types: Other

Identifiers

NCT01655589

IV-01

Details and patient eligibility

About

The main purpose of this study is to investigate the association between VEGF gene polymorphism and the response to intravitreal drugs in neovascular age-related macular degeneration. This is a retrospective review of patients treated between 2008 and 2012 at the Institute of Vision, in Belo Horizonte, Brazil.

Enrollment: 74 estimated patients

Sex: All

Ages: 50+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosis of neovascular age-related macular degeneration
• Visual acuity better than 20/400
• Loading dose with three intravitreal injections of anti-VEGF agents, administred one per month over three months
• Follow-up period of at least six months

Exclusion criteria

• Choroidal neovascularization secondary to any other cause than age-related macular degeneration
• Eyes with polypoidal choroidal vasculopathy
• Eyes previously submitted to posterior vitrectomy
• Other diseases that could affect visual acuity