VEGF in Iris Tissue in Primary Congenital Glaucoma

Hassan Lotfy Fahmy

Status: Not yet enrolling

Conditions: Iris

Treatments: Other: Immunohistochemistry analysis

Study type: Interventional

Funder types: Other

Identifiers

NCT05484050

2323300

Details and patient eligibility

About

Estimation of vascular endothelial growth factor (VEGF) in iris tissue specimen in primary congenital glaucoma through Immunohistochemistry.

Full description

Combined trabeculotomy with mitomycin C will done in infants with primary congenital glaucoma with histopathological examination of the the peripheral iris tissue specimen and vascular endothelial growth factor (VEGF) estimation in iris tissue specimen through Immunohistochemistry.

Estimation of vascular endothelial growth factor (VEGF) in iris tissue specimen taking from ocular trauma or congenital cataract used as control.

Enrollment: 30 estimated patients

Sex: All

Ages: 1 day to 1 year old

Volunteers: No Healthy Volunteers

Inclusion criteria

• primary congenital glaucoma

Exclusion criteria

• Infants with history of previous surgery.
• Secondary glaucoma.
• Glaucoma associated with other congenital anomalies.

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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30 participants in 2 patient groups

VEGF in iris tissue in primary congenital glaucoma

Other group

Description:

Estimation of VEGF grade in iris tissue in primary congenital glaucoma through Immunohistochemistry

Treatment:

Other: Immunohistochemistry analysis

VEGF in iris tissue from ocular trauma or congenital cataract

Other group

Description:

Estimation of VEGF grade in iris tissue from ocular trauma or congenital cataract through Immunohistochemistry

Treatment:

Other: Immunohistochemistry analysis