VEGF Signaling Promotes Cell Growth and Metastasis in Hepatocellular Carcinoma in a VEGF Receptor Mediated Pathway (HCC)

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Sun Yat-sen University

Status

Unknown

Conditions

Hepatocellular Carcinoma

Treatments

Procedure: surgical treatment

Study type

Observational

Funder types

Other

Identifiers

NCT01892072
k0113011-2013VEGF

Details and patient eligibility

About

The investigators study the VEGF signaling in HCC cell lines and its mechanism in HCC growth, proliferation and apoptosis.

Full description

Several studies have documented the elevated expression of VEGF, VEGFR1 and VEGFR2 in HCC cell lines and tumor tissues. Another study observed a sequential elevation of VEGF in low-grade dysplasia, high-grade dysplasia and early stage HCC. Clinical analyses have discovered the high expression of VEGF is correlated with tumor progression, vascular invasion, distal metastasis and poor prognosis. However, few studies have been conducted to investigate the VEGF signaling in HCC cells and its possible mechanism in regulating HCC growth.Therefore,we try to clarify the mechanism of VEGF signal in HCC growth,proliferation and apoptosis.

Enrollment

50 estimated patients

Sex

All

Ages

16 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • hepatocellular patients diagnosed through biopsy;or either dynamic imagine with a diagnosis of hepatocellular carcinoma and alphafetoprotein>400μg/L;or two or more dynamic imagine with a diagnosis of hepatocellular carcinoma
  • Child-Pugh A or B
  • well preserved renal and hematopoietic Function
  • receive surgical therapy
  • achieve complete section accessed by contrast-enhanced CT

Exclusion criteria

  • incomplete section
  • remote metastasis
  • Child-Pugh C
  • combination with other hepatobiliary disease
  • suffer from other tumors concurrently or in last five years

Trial design

50 participants in 1 patient group

HCC patients
Description:
Hepatocellular carcinoma patients treated by surgical treatment
Treatment:
Procedure: surgical treatment

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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