Venoarterial PCO2 Difference /Arteriovenous O2 Content Difference Ratio as Goal of Early Septic Shock Therapy

Chinese Academy of Medical Sciences & Peking Union Medical College

Status: Unknown

Conditions: Septic Shock

Treatments: Procedure: volume resuscitation, vasoactive drug

Study type: Interventional

Funder types: Other

Identifiers

NCT01877798

PCSS

Details and patient eligibility

About

Reducing tissue hypoxia is the ultimate goal of severe sepsis and septic shock therapy.Venoarterial PCO2 difference /arteriovenous O2 content difference ratio (△PCO2/Ca-vO2) is considered to be a good indicator of global anaerobic metabolism.The purpose of this study was to compare the efficacy of △PCO2/Ca-vO2 and central venous oxygen saturation (ScvO2) in the treatment of severe sepsis and septic shock.

Enrollment: 300 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• severe sepsis and septic shock patients

Exclusion criteria

• <18 years old
• pregnant and breast-feed woman
• AMI
• cerebral hemorrhage
• contraindication for central venous catheter or arterial catheter;
• brainstem death

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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300 participants in 2 patient groups

△PCO2/Ca-vO2

Experimental group

Description:

△PCO2/Ca-vO2 directed group

Treatment:

Procedure: volume resuscitation, vasoactive drug

ScvO2

Experimental group

Description:

ScvO2 directed group

Treatment:

Procedure: volume resuscitation, vasoactive drug