Venous Congestion and Organ Dysfunction. (CoDoRéa)

University Hospital Center (CHU) Dijon Bourgogne

Status: Completed

Conditions: Organ Dysfunction Syndrome; Venous Congestion

Treatments: Other: collection of echographic parameters; Other: collection of clinical parameters; Other: collection of biological parameters

Study type: Observational

Funder types: Other

Identifiers

NCT04680728

GUINOT 2020

Details and patient eligibility

About

Venous congestion, which is a phenomenon described in cardiology and post-operative cardiac surgery, is responsible for an increase in morbidity and mortality.

Indeed, it can lead to kidney failure, liver failure, prolonged ileus, scarring complications, and neurological disorders. Clinical and ultrasound indications have been described to diagnose this condition.

To date, this phenomenon is poorly known and not described in intensive care patients outside the cardiac context. However, intensive care patients can present the risk factors associated with the occurrence of congestion: acute cardiac failure, significant water-salt overload, and/or fluid distribution anomalies. Thus, observational studies have found an association between the input-output balance, the quantity of salt-water intake, the presence of right heart dysfunction and the occurrence of acute kidney failure, digestive disorders, hypoxemia and a prolonged stay in intensive care. The presence of a congestive condition is medically treatable since diuretic decongestion is associated with improved cardiac outcomes.

It is therefore necessary, in an intensive care context, to be able to define and diagnose this state of venous congestion, to study its prevalence, and to confirm the existence of a link with organ failure in order to pave the way to known adapted treatment options.

Enrollment: 185 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult
• Patient who has expressed his or her non-opposition to the collection of data (or the health care proxy, or a close relative if the patien is unable to receive the information)
• Patient admitted to intensive care for less than 24 hours.

Exclusion criteria

• Person not affiliated to the national health insurance
• Minor, protected major
• Pregnant or breastfeeding women
• Anechogenicity confirmed by the operator
• Chronic atrial fibrillation
• Mechanical cardiac assistance
• Uncontrolled blood pressure (MAP < 65 mmHg)

Trial design

185 participants in 1 patient group

patient

Description:

Patient admitted to intensive care for less than 24 hours.

Treatment:

Other: collection of biological parameters

Other: collection of clinical parameters

Other: collection of echographic parameters