Ventilation and Esophageal Pressure Changes

University of California (UC) Davis

Status: Completed

Conditions: Mechanical Ventilation

Study type: Observational

Funder types: Other

Identifiers

NCT05859672

1903822

Details and patient eligibility

About

A study to observe the effect of variations in ventilator settings including tidal volume and PEEP on transpulmonary pressure monitored with an esophageal balloon catheter and to correlate intraoperative transpulmonary pressure variations and intraoperative stroke volume variation changes.

Full description

This study seeks to observe the effects of variations in ventilator settings on transpulmonary and intrathoracic pressures. More specifically, to observe the impact of variations in tidal volume from 6 mL/kg to 8 mL/kg and PEEP from 0 cm of water (H2O) to 5 cm H2O on transpulmonary and intrathoracic pressures monitored with an esophageal balloon catheter. The impact of this recommended decrease in tidal volume on the clinical utility of stroke volume variation (SVV) as a guide for fluid administration has not been previously examined.

Enrollment: 150 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients scheduled for elective surgery requiring general anesthesia and endotracheal intubation.
• Age ≥ 18

Exclusion criteria

• Patients undergoing planned esophageal surgery
• Patients with significant nasal or esophageal pathology
• Adults unable to consent
• Individuals who are not yet adults (infants, children, teenagers)
• Pregnant women
• Prisoners