Ventilation Associated Pneumonia and Covid-19 (ECOLCOVID)

Centre Hospitalier Universitaire de Nīmes

Status: Completed

Conditions: COVID-19; Ventilator Associated Pneumonia; SARS-CoV2 Infection; Ards

Study type: Observational

Funder types: Other

Identifiers

NCT05089968

LOCAL/2021/LC-01

Details and patient eligibility

About

In December 2019, a new pandemic emerged, the COVID-19 disease caused by a SARS-Cov-2 virus. One of the most common symptoms of COVID-19 is mainly respiratory failure and patients requires assistance by mechanical ventilation. Ventilator-associated pneumonia (VAP) is a risk of this assistance. Since the beginning of the pandemic, Standard of care have evolved with new data. The prevalence of these VAPs seems significantly higher in the population of patients with ARDS COVID-19 (40-50%) and their ecology seems to have evolved over time, particularly in terms of bacterial resistance. Investigators want to describe and compare this evolution of bacterial and fungal ecology as well as identify potential risk factors that may be associated with these changes in ecology during different waves.

Enrollment: 268 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Age > 18 years
• Positive SARS-Cov-2 polymerase chain reaction (PCR)
• healthcare associated pneumonia

Exclusion Criteria : Patient opposition to participate to the study

Trial design

268 participants in 2 patient groups

Patient from the first wave of COVID-19

Description:

57 Patients hospitalized in intensive care unit for pneumonia related to a Sars-Cov2 infection who required mechanical ventilatory support and developed microbiologically documented ventilator associated pneumonia during the 1st wave from January 24, 2020 to July 10, 2020

Patient from the Second wave of COVID-19

Description:

211 Patients hospitalized in intensive care unit for pneumonia related to a Sars-Cov2 infection who required mechanical ventilatory support and developed microbiologically documented ventilator associated pneumonia during the 2nd wave from July 11, 2020 to January 8, 2021