Ventilation Heterogeneity Prior to Lung Resection

McMaster University

Status: Invitation-only

Conditions: Lung Cancer

Treatments: Other: Hyperpolarized 129Xe MRI; Other: Sputum Induction; Other: Technegas V SPECT

Study type: Observational

Funder types: Other

Identifiers

NCT04191174

FIRH_Xe004

Details and patient eligibility

About

This is a single centre prospective six-week observational study to understand the prevalence and clinical relevance of abnormal ventilation of the lung (assessed by Technegas ventilation single photon emission computed tomography (V SPECT) and hyperpolarized 129Xe magnetic resonance imaging (MRI)), in the presence or absence of airway inflammation (assessed by sputum cell counts), in lung cancer patients prior to lung resection surgery.

Enrollment: 115 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Undergoing lung resection for lung cancer at St. Joseph's Healthcare (Hamilton, Ontario) in accordance with British Thoracic Society guidelines.
• Males and females ≥ 18 years of age.
• Able and willing to provide written informed consent.
• Able and willing to comply with the study protocol.

Exclusion criteria

• Previous lung resection surgery.
• Previous chest radiation.
• Patient has an implanted mechanically, electrically or magnetically activated device or any metal in their body which cannot be removed, including but not limited to pacemakers, neurostimulators, biostimulators, implanted insulin pumps, aneurysm clips, bioprosthesis, artificial limb, metallic fragment or foreign body, shunt, surgical staples.
• In the investigator's opinion, subject suffers from any physical, psychological or other condition(s) that might prevent performance of the MRI, such as severe claustrophobia.
• Pregnancy.

Trial design

115 participants in 1 patient group

Adults undergoing lung resection for lung cancer

Treatment:

Other: Sputum Induction

Other: Technegas V SPECT

Other: Hyperpolarized 129Xe MRI