Ventilator-driven Alveolar Recruitment Maneuver

Samsung Medical Center

Status: Completed

Conditions: Recruitment; Ventilator Lung; Atelectasis; Postoperative Atelectasis

Treatments: Other: Alveolar recruitment maneuver

Study type: Interventional

Funder types: Other

Identifiers

NCT04258202

SMC2019-11-117-003

Details and patient eligibility

About

During laparoscopic surgery, gas infiltration and head down position cause pulmonary atelectasis. Alveolar recruitment maneuvers are beneficial in reopening collapsed alveoli and improving lung mechanics. Ventilator-driven Alveolar recruitment maneuvers may restore lung volume but it remains unknown which method is most effective. The primary aim was to compare the efficacy of two ventilator-driven ARMs method using incremental tidal volume or positive end expiratory pressure(PEEP) until plateau pressure 30 cmH20 (within driving pressure 20 cmH20).

Full description

General anesthesia promotes the formation of atelectasis, which negatively impacts respiratory function and may be associated with subsequent pulmonary complications. Especially, during laparoscopic surgery, gas infiltration and head down position cause pulmonary atelectasis. Alveolar recruitment maneuvers are beneficial in reopening collapsed alveoli and improving lung mechanics, suggesting that performing an Alveolar recruitment maneuvers after intubation, circuit disconnection, position change, intraabdominal gas infiltration.

Conventional manual ARM is performed by sustained lung inflation using the reservoir bag on the anaesthesia machine with the adjustable pressure-limiting valve set to the desired inflation pressure. However, the manual ARM can lead to brief loss of positive pressure when switching back to the ventilator circuit, which results in re-collapse of alveoli. For this reason, investigators try to compare the methods of the ventilator-driven ARM.

Enrollment: 64 patients

Sex: All

Ages: 20 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients who receive laparoscopic surgery in trendelenberg position

Exclusion criteria

• Patients who are simultaneously participating in other studies
• Patients who are scheduled to leave the intensive care unit after surgery
• Patients with obstructive or restrictive pattern of Severe or moderate grade on Pulmonary function test
• High risk in cardiovascular events (expected postoperative cardiovascular event > 5%)
• Patients with emphysema confirmed by imaging test
• patients with obesity BMI > 35 kg / m2

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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64 participants in 2 patient groups

positive end expiratory pressure group

Experimental group

Description:

Alveolar recruitment maneuver is performed after intubation, pneumoperitoneum, closure of abdominal fascia. PEEP increased in a stepwise manner from 5 to 20 cmH2O, until plateau pressure 30 cmH2, then 10 breaths. After recruitment, ventilation sets at tidal volume 7 mL/kg with positive end expiratory pressure (PEEP) 5cmH2O.

Treatment:

Other: Alveolar recruitment maneuver

tidal volume group

Experimental group

Description:

Alveolar recruitment maneuver is performed after intubation, pneumoperitoneum, closure of abdominal fascia. Tidal volume increased in steps of 4mL/kg of ideal body weight until plateau pressure 30 cmH2O, then 10 breaths. After recruitment, ventilation sets at tidal volume 7 mL/kg with PEEP 5 cmH2O.

Treatment:

Other: Alveolar recruitment maneuver