Ventilator Mode and Respiratory Physiology

University of California San Diego

Status: Invitation-only

Conditions: Respiratory Effort; Respiratory Failure; Pulmonary Disease; Breathing Mechanics

Treatments: Other: lung mechanics, respiratory drive and effort

Study type: Observational

Funder types: Other

Identifiers

NCT06624254

807319

Details and patient eligibility

About

Modern intensive care units (ICUs) are increasingly adopting newer modes of mechanical ventilation such as adaptive pressure control (APC) modes but there are limited data available regarding risks and benefits of newer modes versus traditional ventilation modes. APC can inadvertently deliver high tidal volumes, which maybe harmful. High tidal volumes may be unrecognized by the provider, due to the complexities of ventilator algorithms and patient interactions. The objective of this aim is to identify risk factors for excess tidal volumes in patients on adaptive pressure control.

Enrollment: 60 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Admitted to ICU with acute respiratory failure
• On adaptive pressure control mode of ventilation
• Tidal volumes set between 5-8 cc/kg ideal body weight

Exclusion criteria

• Current use of neuromuscular blockade
• Inability to obtain consent from patient or surrogate decision maker
• Treating clinician refusal

Trial design

60 participants in 1 patient group

Adaptive Pressure Control

Description:

On adaptive pressure control mode with acute respiratory failure

Treatment:

Other: lung mechanics, respiratory drive and effort