Ventilatory Responses to Hypercapnic and Hypoxic Conditions in Hyperventilants

Centre Hospitalier Universitaire Saint Pierre

Status: Completed

Conditions: Hyperventilation Syndrome; Hypercapnia; Hypoxia

Treatments: Diagnostic Test: Hypercapnic hyperoxic ventilatory response; Diagnostic Test: Hypoxic eucapnic ventilatory response

Study type: Interventional

Funder types: Other

Identifiers

NCT05189158

B076201836758 -2

Details and patient eligibility

About

For almost a century, many hypotheses have converged on the idea of altered chemosensitivity in patients suffering from hyperventilation syndrome (HVS).

Given the evolution of current technical equipment and the ability to maximise true positives in HVS ( using the revised hyperventilation provocation test), it seems reasonable to investigate central and peripheral chemosensitivities in HVS subjects.

Full description

In the inter-war period, many medical investigators who studied the hyperventilation syndrome (HVS) had already questioned the chemosensitivity to CO2 in HVS patients, without being able to explore it for all intents and purposes.

It was subsequently observed that although HVS is not systematically linked to manifest resting hypocapnia, it is nevertheless systematically correlated with significant variability and complexity of ventilation.

This is consistent with the observations of an increased plant gain in HVS, to be related to an increased loop gain (due to instability of controller gain feedback).

On the other hand, some authors already noted that, when capnia is chronically compromised in HVS, it can be greatly altered by small, transient and barely perceptible increases in VE: a 10% increase in VE could indeed halve PetCO2, while a sigh would be able to decrease PetCO2 by up to 15mmHg.

More recently, teh assumption was made that peripheral chemosensitivity may be impaired in HVS patients.

For all these considerations, it seems reasonable to investigate central and peripheral chemosensitivities in identified HVS subjects on the basis of an objective test, such as the induced hyperventilation test.

Enrollment: 24 patients

Sex: All

Ages: 18 to 99 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• A plethysmography within subject's predicted values
• A negative metacholine test (no documented allergy)
• A hyperventilation provocation test result that is consistent with the Nijmegen questionnaire score, confirming either group classification (HVS+ or HVS-)

Exclusion criteria

• Each of the following known or documented conditions: chronic bronchitis (COPD), emphysema, asthma, cardiac disorder, neurological disorder, gastrointestinal disorder, thyroid disorder or psychological/psychiatric disorder
• Suspicious cardio-pulmonary exercise testing (CPET) with cardiac or respiratory limitation
• Pregnant women or women in the process of becoming pregnant
• Persons with a diving practice (amateur or professional),
• High-level athletes,
• Active smokers and
• persons using morphine, and/or barbiturates, and/or anxiolytics and/or sleeping pills

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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24 participants in 2 patient groups

HVS-

Other group

Description:

subjects with no complaint AND a Nijmegen questionnaire score of \< 23/64 AND a negative hyperventilation provocation test (criteria revised in 2021) (HVS-)

Treatment:

Diagnostic Test: Hypercapnic hyperoxic ventilatory response

Diagnostic Test: Hypoxic eucapnic ventilatory response

HVS+

Other group

Description:

subjects with complaints AND a Nijmegen questionnaire score of ≥23/64 AND a negative hyperventilation provocation test (criteria revised in 2021) (HVS+)

Treatment:

Diagnostic Test: Hypercapnic hyperoxic ventilatory response

Diagnostic Test: Hypoxic eucapnic ventilatory response