VentricuLostomy AssoCiaTed InfeCtions (LACTIC): Focus on CSF Lactate and Sampling Site

Rigshospitalet

Status: Enrolling

Conditions: Hydrocephalus; External Ventricular Drain; External Ventricular Drainage Associated Infection; Acute Brain Injury

Treatments: Other: Sampling of blood and cerebrospinal fluid

Study type: Observational

Funder types: Other

Identifiers

NCT07380477

p-2024-17691 (Other Identifier)

H-24051777

Details and patient eligibility

About

This observational study involving patients with acute brain injury undergoing treatment with an external ventricular drain consists of three subprojects, aiming to:

1. investigate various biomarkers, with a primary focus on the development of cerebrospinal fluid lactate in relation to ventriculostomy-associated infection;
2. compare proximal and distal sample results obtained from an external ventricular drain;
3. describe the natural progression of various biomarkers in blood and cerebrospinal fluid following acute brain injury.

Enrollment: 148 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age >18 years
• EVD in situ
• Admission to the neuro-ICU or neurosurgical step-down unit at Rigshospitalet, Denmark
• Diagnosis of acute brain injury categorized as traumatic brain injury, subarachnoid haemorrhage, intracranial haemorrage, intraventricular haemorrhage

Exclusion criteria

• Patient or closest relatives do not understand written and spoken Danish or English
• Patients transferred to Rigshospitalet with an EVD
• Patients with brain injury due to existing brain infection (e.g., meningitis, intracranial empyema or abscess, encephalitis)
• Patients with existing ventriculoperitoneal or ventriculoatrial shunt at the time of admission
• Patients with primary or secondary brain cancer
• Patients died or in palliative care