Vericiguat for Heart Failure With Reduced Ejection Fraction After Myocardial Infarction (HFrEF)

Shandong University

Status: Not yet enrolling

Conditions: HFrEF - Heart Failure With Reduced Ejection Fraction; Myocardial Infarction (MI)

Treatments: Drug: Vericiguat Oral Tablet [Verquvo]; Drug: Prescription Drugs

Study type: Observational

Funder types: Other

Identifiers

NCT06717204

Vericiguat for HFrEF

Details and patient eligibility

About

The effects of vericiguat on cardiac remodeling in patients with chronic stable heart failure after myocardial infarction have not been reported. This project aims to clarify the efficacy and safety of vericiguat in patients with chronic heart failure after myocardial infarction. Patients with chronic stable heart failure with reduced ejection fraction after myocardial infarction in the electronic medical records of Qilu Hospital of Shandong University will be selected and divided into two groups: the treatment group received vericiguat in addition to conventional treatment and the control group received conventional treatment only. After 12-month treatment, the effects of vericiguat on cardiac remodeling and function and cardiovascular adverse events will be evaluated. The results are helpful to provide a new treatment strategy for chronic heart failure after myocardial infarction.

Enrollment: 210 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. The history of acute myocardial infarction exceeds 3 months;
2. Symptoms and signs of heart failure have been stable for more than one month;
3. 18 years old or more;
4. NYHA cardiac function classified as grade II~IV;
5. LVEF≤40%；
6. NT-proBNP≥450pg/ml；
7. All subjects or their guardians must sign the subject consent before entering the trial.

Exclusion criteria

1. Patients with the following diseases: nonischemic cardiomyopathy; valvular heart disease; congenital heart disease; obstruction of left ventricular outflow tract; severe decompensated heart failure; active myocarditis or pericardial disease; end-stage liver and kidney diseases; malignant tumor;
2. Mechanical complications of myocardial infarction;
3. Unable to obtain primary outcome data.

Trial design

210 participants in 2 patient groups

Vericiguat and conventional treatment

Description:

Vericiguat in addition to conventional treatment

Treatment:

Drug: Prescription Drugs

Drug: Vericiguat Oral Tablet [Verquvo]

Conventional treatment only

Description:

Conventional treatment only

Treatment:

Drug: Prescription Drugs