Verification of Saliva MMP-1 as a Diagnostic Marker of Oral Cavity Cancer

S&T Biomed

Status: Completed

Conditions: Oral Squamous Cell Carcinoma

Treatments: Diagnostic Test: MMP-1 Enzyme Linked Immunosorbent assay (ELISA)

Study type: Observational

Funder types: Industry

Identifiers

NCT05049408

STBM-CT-OSCC-DIA001

Details and patient eligibility

About

The study is designed to measure salivary matrix metalloproteinase-1 (MMP-1) using the enzyme-linked immunosorbent assay (ELISA) we developed previously in patients with oral potentially malignant disorders (OPMD), oral squamous cell carcinoma (OSCC), and healthy participants. The purpose of this study is to evaluate the potential of the newly developed salivary MMP-1 ELISA as an adjunctive tool to aid in diagnosis of OSCC.

Enrollment: 1,160 patients

Sex: All

Ages: 20+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Group OSCC: patients with lesions of OSCC
• Group OPMD: patients with lesions of OPMD
• Group HC: healthy subjects who are not suffering from any oral lesions and having behaviors of smoking, and/or betel nut chewing

Exclusion criteria

• Subjects having personal history of other cancers or severe diseases

Trial design

1,160 participants in 3 patient groups

Group OSCC

Description:

Patients with Oral Squamous Cell Carcinoma (OSCC)

Treatment:

Diagnostic Test: MMP-1 Enzyme Linked Immunosorbent assay (ELISA)

Group OPMD

Description:

Patients with oral potentially malignant disorders (OPMD)

Treatment:

Diagnostic Test: MMP-1 Enzyme Linked Immunosorbent assay (ELISA)

Group HC

Description:

Healthy Control

Treatment:

Diagnostic Test: MMP-1 Enzyme Linked Immunosorbent assay (ELISA)