VERRARI - "Are Ventricular Arrhythmic Episodes Reduced by Rate Response in ICDs?"

Guidant

Status and phase

Completed

Phase 4

Conditions

Ventricular Fibrillation

Treatments

Device: ICD

Study type

Interventional

Funder types

Industry

Identifiers

NCT00180427

Version vom 01.03.2001

Details and patient eligibility

About

"The purpose of this study is to evaluate the influence of the rate response function of implantable cardioverter defibrillators (ICDs) on the frequency of ventricular arrhythmias in patients with an ICD."

Full description

"Background: Studies have shown that bradycardia and irregular heart rates may increase the incidence of ventricular arrhythmias. Regularizing the heart rate and avoiding bradycardias by rate responsive pacing may be a way to reduce these arrhythmias.

This is a prospective, open-label, randomized multicenter study. Inclusion criteria: Patients with an indication for an ICD according to the AHA/ACC-guidelines who get a rate response system and have more than 5 % rate adaptive pacing during a one month screening phase may be included if they have given written informed consent. Rate adaptive pacing must not be contraindicated, patients must be able to perform a 6 min walk test, must not be NYHA IV and should have a life expectancy of more than 18 months.

Patients will be randomly assigned to 6 months of rate responsive pacing followed by 6 months of no rate responsive pacing, vice versa respectively. At 6 and 12 months follow ups, ICD stored data, arrhythmic episodes, medication, anamnesis, quality of life, 6 min walktest, echocardiographic parameters and optionally spiroergomatry will be evaluated and compared."

Sex

All

Ages

18 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

indication for an ICD according to ACC/AHA guidelines
ICD with rate response function implanted
at least 5% rate response ventricular pacing during the one month screening phase
signed informed patient consent"

Exclusion criteria