Verticality Perception - Effects of Prolonged Roll-tilt in Healthy Human Subjects

University of Zurich (UZH)

Status: Withdrawn

Conditions: Perception; Vestibular

Treatments: Other: perception of vertical after static roll-tilt over 5min

Study type: Interventional

Funder types: Other

Identifiers

NCT02760173

vert_perc_posttilt

Details and patient eligibility

About

The long-term goal of this research is to advance our knowledge of how the brain combines the information of multiple sensory systems coding for spatial orientation and how adaptation to vestibular imbalance influences spatial orientation. In healthy human subjects verticality perception is accurate while upright. After prolonged roll-tilt, humans show a systematic bias in perceived direction towards the previous roll-tilted position (so-called "post-tilt bias"). Here we evaluate different potential explanations for this bias using both vision-dependent and vision-independent paradigms of verticality perception.

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. ages 18-65 years
2. informed consent
3. absence of exclusion criteria

Exclusion criteria

1. peripheral-vestibular deficit
2. disturbed consciousness
3. history of sensory deficits
4. visual field deficits
5. other neurological or systemic disorder which can cause dementia or cognitive dysfunction
6. intake of antidepressants, sedatives, or neuroleptics
7. pregnancy, unless excluded by a negative pregnancy test
8. known neck pain or status post neck trauma

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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0 participants in 1 patient group

Single intervention arm

Experimental group

Description:

This is the only arm in this study, measuring verticality perception after prolonged roll-tilt over 5min.

Treatment:

Other: perception of vertical after static roll-tilt over 5min