Verticality Perception in Stroke Patients

University of Zurich (UZH)

Status: Unknown

Conditions: Verticality Perception in Stroke

Treatments: Other: presentation of visual vertical

Study type: Interventional

Funder types: Other

Identifiers

NCT02184923

verticality_percept_stroke_zrh

Details and patient eligibility

About

The long-term goal of this research is to advance our knowledge of how information from the labyrinth is brought to perception and how adaptation to vestibular imbalance influences spatial orientation. In healthy human subjects verticality perception is accurate while upright.The strategy of this research is to quantify changes in verticality perception after unilateral lesions along the central graviceptive pathways and to assess the frequency and pattern of abnormal verticality perception in patients with acute stroke (ischemic or hemorrhagic). Our underlying hypothesis is that screening for erroneous verticality perception by use of a mobile device assessing the subjective visual vertical (SVV) during the acute phase (i.e., within 24-48 hours after symptom onset) reliably identifies those patients with defects. Early detection of deficits in verticality perception may help to initiate balance physiotherapy early.

Enrollment: 130 patients

Sex: All

Ages: 18 to 90 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. ages 18-90 years
2. informed consent
3. for group 1: acute (i.e. symptom onset <3 days ago) lateralized ischemia or hemorrhage as confirmed by clinical examination and / or brain imaging (CT or MRI).
4. absence of exclusion criteria

Exclusion criteria

1. history of a peripheral-vestibular deficit
2. disturbed consciousness
3. severe sensory or motor aphasia
4. visual field deficits
5. other neurological or systemic disorder which can cause dementia or cognitive dysfunction
6. intake of antidepressants, sedatives, or neuroleptics

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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130 participants in 1 patient group

verticality measurements

Experimental group

Treatment:

Other: presentation of visual vertical