Very Small Embryonic-like Stem Cells for Facial Skin Antiaging

Fuda Cancer Hospital, Guangzhou

Status and phase: Withdrawn; Phase 2; Phase 1

Conditions: Skin Inflammation; Stem Cell Transplant Complications

Treatments: Biological: Very small embryonic-like stem cell

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT03976206

VSEL-face

Details and patient eligibility

About

The aim of this study is the safety and efficacy of autologous very small embryonic-like stem cells(VSELs) to facial skin antiaging.

Full description

VSELs come from the patient's peripheral blood, and will be injected in left preauricular area, followed by skin pathology to compare the improvement of skin aging. Two 0.5 × 1 cm fragments of skin and subcutaneous tissue was removed from bilateral preauricular areas for morphologic analysis by optical and electron microscopy. Histologic analysis of skin biopsy specimens was performed by hematoxylin and eosin, picrosirius red (for visualization of collagen), and orcein (for visualization of elastic fibers) staining.

Sex: All

Ages: 40 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy volunteers with anti-aging willingness

Exclusion criteria

• Metabolic and systemic diseases such as diabetes and atherosclerosis
• Facial skin diseases such as herpes, eczema, skin rash, systemic lupus erythematosus, dermatomyositis, connective tissue disease
• Endocrine disorders and cancer patients Blood disease patients, thrombocytopenia or dysfunction, hypofibrinemia or anticoagulant therapy, long-term use of aspirin

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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0 participants in 4 patient groups

VSEL Max

Experimental group

Description:

We carried out the subdermal application of VSELs with a 1-mL syringe (90,000 cells in 0.4 mL plate-rich plasma) coupled to a 30-gauge needle, in the left preauricular area (1-cm2 area), 2 cm distal from the tragus

Treatment:

Biological: Very small embryonic-like stem cell

VSEL Medium

Experimental group

Description:

We carried out the subdermal application of VSELs with a 1-mL syringe (60,000 cells in 0.4 mL plate-rich plasma) coupled to a 30-gauge needle, in the left preauricular area (1-cm2 area), 2 cm distal from the tragus

Treatment:

Biological: Very small embryonic-like stem cell

VSEL Mini

Experimental group

Description:

We carried out the subdermal application of VSELs with a 1-mL syringe (30,000 cells in 0.4 mL plate-rich plasma) coupled to a 30-gauge needle, in the left preauricular area (1-cm2 area), 2 cm distal from the tragus

Treatment:

Biological: Very small embryonic-like stem cell

Control

No Intervention group

Description:

Subcutaneous injection of 0.4 mL platelet-rich plasma in the same part of the experimental group