Vescell(TM) for the Treatment of Patients With Severe Anginal Syndrome With or Without Heart Failure

TheraVitae

Status and phase

Unknown

Phase 2

Phase 1

Conditions

Angina Pectoris

Treatments

Procedure: Intracoronary administration of autologous ACPs

Study type

Interventional

Funder types

Industry

Identifiers

NCT00416663

TV-013

Details and patient eligibility

About

Evaluation of an intracoronary injection of ex-vivo generated autologous Angiogenic Cells Precursors (ACPs) to treat patients suffering from severe angina not responsive to maximal drug treatment or not willing or without option of undergoing percutaneous coronary intervention (PCI) or coronary artery bypass graft surgery (CABG). The use of ACPs aims to promote the formation of new vascularization and thus viable myocardial tissue.

Full description

Ten adult patients with severe angina pectoris with or without heart failure and no therapeutic alternative will undergo screening and be treated with an injection of Angiogenic Cell Precursors (ACPs), contained in VesCell (TM). 250 ml of blood will be drawn from the patient and from this blood sample progenitor cells will be generated and differentiated into ACPs. The product will be administered into the obstructed coronary arteries using a catheter. Following injection, patients will be hospitalized for 24-48 hours in intensive care and later as required by their medical condition. Patients will return for follow up testing at one, three and six months following treatment.

Enrollment

10 estimated patients

Sex

All

Ages

18 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patients with chronic stable angina on maximal medical therapy and an occluded coronary artery or bridging collaterals to a patent distal segment supplying an ischemic viable myocardial region as shown on Sestamibi scan. On coronary angiography, the occluded coronary artery or bridging collaterals must have a patent proximal segment of at least 30 mm with at least one side branch to enable the injection of the VesCellTM if the vessel remains occluded despite the attempted angioplasty efforts (prior to or during the study angiography).
Patients with occluded target coronary artery (with or without bridging collaterals) that could not be treated with PCI.
Patients are not candidates for or are not willing to undergo CABG surgery.
Age 18 to 80 years
Male or non-pregnant, non-lactating female
Ejection fraction >35% on Sestamibi
Sestamibi scan (myocardial perfusion) during exercise or dipyridamole, demonstrating regional reversible ischemia in an area relating to the occluded coronary artery.
Informed consent obtained and consent form signed

Exclusion criteria

Patients not satisfying the coronary angiography and Sestamibi criteria.
Patient who received blood transfusions during the previous 4 weeks (to exclude the potential of non-autologous ACPs in the harvested blood).
Inability to communicate (that may interfere with the clinical evaluation of the patient)
STEMI during the preceding 3 months
PCI+stenting during the preceding three months
Significant valvular disease or after valve replacement
After heart transplantation
Cardiomyopathy
Renal failure (creatinine 10% above the upper limit according to the hospital normograms)
Hepatic failure
Anemia (lower than 11mg/dl.hemoglobin for female and lower than 12 mg/dl for male)
Abnormal coagulation tests normal [platelets, PT (INR), PTT]
Stroke within the preceding 3 years
Malignancy within the preceding 3 years
Concurrent chronic or acute infectious disease
Severe concurrent medical disease (e.g., septicemia, HIV-1,2/HBV/HCV infections, insulin-dependent diabetes mellitus, systemic lupus erythematosus, multiple sclerosis, amyotrophic lateral sclerosis)
Chronic immunomodulating or cytotoxic drugs treatment
Patients who have rectal temperature above 38.40C for 2 consecutive days
Patient unlikely to be available for follow-up