Vestibular and Multisensory Influence on Bodily and Spatial Representations. Behavioral and Electrophysiological Investigations in Vestibular-defective Patients and Healthy Volunteers

Public Assistance-Hospitals of Marseille (AP-HM)

Status: Completed

Conditions: Vestibular-defective Patients

Treatments: Other: electroencephalography; Other: electromyography; Other: approaches from psychophysics

Study type: Interventional

Funder types: Other

Identifiers

NCT01900457

2013-18 (Other Identifier)

2011-A01221-40

Details and patient eligibility

About

The present project aims at describing how vestibular signals contribute to the multisensory mechanisms of bodily self-consciousness.

There is a large body of data regarding the sensory and neural mechanisms of self-consciousness, but most studies have so far demonstrated the contribution of visual, tactile and proprioceptive signals to bodily self-consciousness. Thus, most studies have neglected the contribution of the vestibular system, a major sensory system for spatial and bodily representations. The vestibular system is sensitive to head motions in space and head inclinations with respect to gravity and it should therefore contribute significantly to several bodily experiences. This contribution should be put under neuroscientific scrutiny. We believe that the current neuroscientific models of bodily self-consciousness will be incomplete until they incorporate the contribution of vestibular signals.

The present project specifically aims at testing the hypothesis according to which vestibular signals significantly influence bodily self-consciousness, in particular first-person and third-person perspective taking and the internal body models (i.e. the body schema and body image). The present project also aims at describing how cortical vestibular processing is modified during experimental changes of perspective taking and viewpoint. In addition, the present project will describe whether vestibular disorders change performances in third-person perspective taking tasks and modify internal body models. This should help understanding bodily symptoms in vestibular-defective patients. To this end, we will combine approaches from psychophysics and electrophysiology (electromyography, electroencephalography) in healthy volunteers and behavioral approached in patients with vestibular disorders.

These studies should further the understanding of how the brain processes vestibular signals, which is to date poorly understood. In addition, the outcome of the present project should help understanding the multiple and complex symptoms reported by patients with vestibular diseases, and should therefore improve their treatment.

Enrollment: 208 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• men(people) or women from 18 to 65 years old
• patients having benefited from a surgical operation (neurotomie vestibulaire unilateral) within the framework of a disease of invalidating Ménière or a neurinome of the accoustique, or patients with an acute(sharp) infringement(achievement) of the system vestibulaire.

Exclusion criteria

The patients suffering from an additional hurt of the central nervous system,

• the patients suffering from driving infringements(achievements),
• the subjects having neurological histories (other than those led(inferred) by the disorders(confusions) vestibulaires) or psychiatric,
• the vulnerable persons aimed by articles L. 1121-5, L. 1121-6 and L. 1121-8,
• the persons unfit of the reading and the writing of French not allowing the understanding of the note of information and the form of consent

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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208 participants in 2 patient groups

Volunteer healthy

Active Comparator group

Description:

healthy volunteers

Treatment:

Other: approaches from psychophysics

patients

Experimental group

Description:

vestibular defective patients

Treatment:

Other: electromyography

Other: electroencephalography