Vestibular Rehabilitation With Intratympanic Drug Therapy in Meniere's Disease

Combined Military Hospital Quetta

Status: Unknown

Conditions: Vestibular Disorder Preservation

Treatments: Drug: Gentamicin; Drug: Dexamethasone

Study type: Interventional

Funder types: Other

Identifiers

NCT05355610

File No: CMH QTA-IRB/043

Details and patient eligibility

About

Intractable symptoms of Meniere's disease will be treated with intratympanic steroids.

At the same time intratympanic dexamethasone will be used to rescue hearing

Full description

For Alleviation of Intractable symptoms of Meniere's disease will be treated with intratympanic steroids. Measured with pre and post therapy vestibular severity index.

At the same time intratympanic dexamethasone will be used to rescue hearing measured with speech reception threshold and speech discrimination threshold

Enrollment: 93 estimated patients

Sex: All

Ages: 24 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All patients of unilateral Meniere's disease with severe vestibular symptoms

Exclusion criteria

• Bilateral disease, operated cases

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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93 participants in 1 patient group

Vestibular severity index improvement

Experimental group

Description:

Improvement in vestibular symptoms with intratympanic gentamicin

Treatment:

Drug: Dexamethasone

Drug: Gentamicin