VF Mapping in Brugada and Early Repolarization Syndromes

Pacific Rim Electrophysiology Research Institute

Status: Completed

Conditions: Early Repolarization Syndrome; Brugada Syndrome

Treatments: Other: radiofrequency ablation

Study type: Observational

Funder types: Other

Identifiers

NCT03764592

PACIFICReri2

Details and patient eligibility

About

To determine the values and limitations of ECGI in guiding ablation and risk stratification in patients with BrS and Early Repolarization.

Full description

The investigators will study symptomatic BrS and ERs syndrome (N=25) and asymptomatic patients (N=25) age between 16-70 years old to determine values and limitations of non-invasive mapping using electrocardiographic imaging (ECGI) in identifying VF substrates as target sites for catheter ablations in patients with Brugada (BrS) and Early repolarization syndromes (ERS) and also determine the mechanisms of VF in BrS and ERs syndromes.

Enrollment: 50 patients

Sex: All

Ages: 16 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Patients presenting with the type1 BrS ECG or ER ECG signature pattern, with/without a sodium channel blocker. Patients with the following one of these symptoms or arrhythmias will be considered as symptomatic patients: 1) aborted cardiac arrest cases, 2) documented VF episodes, 3) agonal respiration during sleep with difficulty to arouse, 4) syncope of unknown origin, or 5) seizure suspected of arrhythmic origin.•

Exclusion criteria

Patients who refuse informed consent and to participate to the best ability in the study.

Patients who have structural heart disease or concomitant medical illness.

Trial design

50 participants in 1 patient group

VF BrS/ERS patients

Description:

Only patients that diagnosed with BrS or ERS based on ECG criteria

Treatment:

Other: radiofrequency ablation