VH-IVUS Plaque Composition Analysis By Fractional Flow Reserve

Inje University

Status: Completed

Conditions: Coronary Disease

Study type: Observational

Funder types: Other

Identifiers

NCT01444599

IB-1110-048

Details and patient eligibility

About

Recent clinical trials demonstrated that virtual histology-intravascular ultrasound (VH-IVUS) is a useful test predicting clinical outcomes of the coronary artery disease (CAD). Thin cap fibroatheroma (VH-TCFA) was proposed a predictor of cardiovascular event by VH-IVUS combined with more than 70% plaque burden and less than 4mm² minimal lumen area (MLA) by IVUS. Fractional flow reserve (FFR) is an established index of the physiological significance of a coronary stenosis. Recent large scale trials demonstrated FFR guided PCI showed favorable clinical outcomes. VH-IVUS represents anatomical severity, but FFR represents functional severity of CAD. Few studies reported relevance between two tests. Aim of this study was to investigate whether the geometry and composition of lesions were different under FFR criteria.

Enrollment: 100 patients

Sex: All

Ages: 20 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• clinical angina pectoris who underwent VH-IVUS and FFR during coronary angiography.
• agree with informed consent

Exclusion criteria

• unable to get informed consent
• low left ventricular ejection fraction less than 35%
• chronic renal failure (Cr>2.0mg/dl)
• acute myocardial infarction related coronary artery
• allergy to adenosine injection

Trial design

100 participants in 2 patient groups

low FFR group (<0.8)

Description:

the patient with FFR values less than 0.8

high FFR group (>0.8)

Description:

the patient with FFR values greater than 0.8