Video-assisted Thoracoscopic Thymectomy Versus Subxiphoid Procedure

The Second Hospital of Shandong University

Status: Enrolling

Conditions: Thymectomy

Treatments: Procedure: VATS surgery procedure; Procedure: Subxiphoid surgery procedure

Study type: Interventional

Funder types: Other

Identifiers

NCT04223466

Subxiphoid ZYP1

Details and patient eligibility

About

Surgerys used in thymectomy for myasthenia gravis and anterior mediastinal tumours have become much less invasive in recent years. In our study, the surgical technique which resected the thymus below the xiphoid process and the technique which was regarded as conventional video- assisted thoracoscopic surgery (VATS) thymectomy was compared.

Enrollment: 100 estimated patients

Sex: All

Ages: 20 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Thymoma with or without myasthenia gravis；
2. Generalized myasthenia gravis not sensitive to conservative medicine treatment;
3. Good cardiopulmonary function.

Exclusion criteria

1. Cardiopulmonary function can't bear surgery;
2. Generalized myasthenia gravis with MuSK(+).

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

---

100 participants in 2 patient groups

Subxiphoid group

Experimental group

Description:

Subxiphoid procedure for thymectomy.

Treatment:

Procedure: Subxiphoid surgery procedure

VATS group

Active Comparator group

Description:

Video-assisted thoracoscopic thymectomy through chest wall.

Treatment:

Procedure: VATS surgery procedure