Viral and Host Factors in the Transmission and Pathogenesis of HIV

Rockefeller University

Status: Terminated

Conditions: HIV Infections

Treatments: Other: blood draw

Study type: Observational

Funder types: Other

Identifiers

NCT00219947

MMA-448

Details and patient eligibility

About

To study the collection of blood from individuals known to be at high risk for HIV-infection or who have been recently infected with HIV.

The data collected are used for diagnostic, prognostic and management decisions as outlined by current HIV-1 Treatment Guidelines.

Full description

This phlebotomy protocol permits the collection of blood from individuals known to be at high risk for HIV-infection or who have been recently infected with HIV.

Participants will have from 10 to 60 ml (approximately 1 to 4 tablespoons) of blood drawn for one or all of the following tests:

• T cell subset enumeration
• Serologic reactivity with HIV antigens
• Viral load assays by bDNA, PCR, or RT-PCR
• Routine Laboratory assessments (chemistries, liver function tests, hepatitis serology, RPR)
• HIV-1 Resistance Testing

These data are used for diagnostic, prognostic and management decisions as outlined by current HIV-1 Treatment Guidelines

Enrollment: 600 patients

Sex: All

Ages: 16+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

recently infected with HIV-1 HIV-1 negative, and at high risk for infection

Exclusion criteria

none

Trial design

600 participants in 2 patient groups

high risk

Description:

Blood draw from individuals known to be or at high risk for HIV-infection

Treatment:

Other: blood draw

diagnosed

Description:

Blood draw f rom individuals diagnosed with HIV infection

Treatment:

Other: blood draw