Viral Respiratory and Gastrointestinal Infections in Children Under 6 Years of Age

University Medical Centre Ljubljana

Status: Unknown

Conditions: Bronchiolitis; Convulsion, Febrile; Gastroenteritis

Study type: Observational

Funder types: Other

Identifiers

NCT00987519

VODP

Details and patient eligibility

About

With the use of molecular methods new viruses have been detected in respiratory and gastrointestinal tracts of both patients and asymptomatic subjects in recent years. The clinical importance of these viruses has not been adequately studied.

The aim of this study is to use molecular methods to detect viruses in upper respiratory tract and gastrointestinal tract of children with acute bronchiolitis, acute gastroenteritis and febrile convulsions and to try to correlate the severity of clinical picture with the amount of viruses present in clinical samples. The investigators will also try to detect the increase in specific antibodies in paired sera.

Enrollment: 1,260 estimated patients

Sex: All

Ages: Under 5 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

presence of

• acute bronchiolitis
• acute gastroenteritis
• febrile convulsion requiring hospital admission

Exclusion criteria

• none

Trial design

1,260 participants in 4 patient groups

Acute bronchiolitis

Description:

Patients with acute bronchiolitis - the presence of nasal discharge, cough, wheezing and/or crackles on lung auscultation.

Acute gastroenteritis

Description:

Patients with 3 or more loose or liquid stools in 24 hours prior to entering the study.

Febrile convulsion

Description:

Patients with a cerebral paroxysm accompanied by fever without signs of central nervous system infection.

Control group

Description:

Patients referred to pediatric surgery for elective surgical procedure - judged to be free of clinical signs and symptoms of infection.