Viral Shedding, Symptoms and Exposure of SARS-CoV-2 in Non-hospitalized Children With COVID-19
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Data on COVID-19 in children are still scarce, and their role in SARS-CoV-2 transmission is poorly described. Furthermore, documentation of the best SARS-CoV-2 sampling methods in children are limited. In adults, saliva seems like a promising specimen to collect by noninvasive procedure to diagnose and monitor viral load of SARS-CoV-2, but this has not been tested in children yet.
We want to test the following hypothesis:
- Shedding load and duration of SARS-CoV-2 in children are related to age, gender, clinical symptoms and exposure
- Salvia samples have equal or higher sensibility than nasal swaps in children for detection of SARS-CoV-2
- Parental home testing of saliva and feces is feasible in children
The study is a prospective cohort study of SARS-CoV-2 PCR-positive children from two test centers in the Capital Region of Denmark. Children aged 0-17 years with a PCR-positive SARS-CoV-2 test from a nasal or pharyngeal swab is included from May 2020 to January 2021 and followed-up for a period of 28 days with weekly sample collection and questionnaires.
Samples include a saliva sample, a nasal swap and a rectal swap for children under four years of age. A semiquantitative RT-PCR method, will identify positive and negative samples and provide a Ct value estimating viral load. Saliva and fecal samples will be analyzed from November 2020-February 2021.
Shedding duration will be related to medial history, clinical presentation, exposure, gender and age.
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- a PCR-positive SARS-CoV-2 test
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Data sourced from clinicaltrials.gov
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