Virotherapy and Natural History Study of KHSV-Associated Multricentric Castleman s Disease With Correlates of Disease Activity

National Cancer Institute (NCI) logo

National Cancer Institute (NCI)

Status and phase

Active, not recruiting
Phase 2

Conditions

HHV-8
Lymphoproliferative Disorder
HIV
Malignancy

Treatments

Drug: Sirolimus
Drug: Rituximab
Drug: Filgrastim (G-CSF)
Other: Observation Only
Drug: Bortezomib
Drug: Vincristine
Drug: Cyclophosphamide
Drug: Doxorubicin
Drug: Valganciclovir
Drug: Interferon-alpha
Drug: Etoposide
Drug: Prednisone
Drug: Zidovudine
Drug: Liposomal Doxorubicin

Study type

Interventional

Funder types

NIH

Identifiers

NCT00092222
04-C-0275
040275

Details and patient eligibility

About

This study will gain information about a rare disorder called KSHV-associated multicentric Castleman s disease (MCD). KSHV, a virus, causes several kinds of cancer, including some forms of MCD. KSHV stands for the Kaposi s sarcoma herpes virus, also called human herpes virus-8, or HHV-8. Researchers want to understand the biology of KSHV-MCD to identify how this disease causes illness and to find ways to treat it. There is no standard therapy effective for all cases of KSHV-MCD. The disease is often fatal, and about half the people who have it die within 2 years of diagnosis. Participants ages 18 and older may be eligible for this study. Participation entails more drawing of blood and having repeated tumor biopsies than if patients received treatment in a non-research setting. Researchers would like to learn more about the relationship of KSHV and Castleman s disease symptoms, and they want to obtain at least three biopsies in this study. There are some side effects of experimental therapy that participants may take for KSHV-MCD. Zidovudine, or Retrovir , is used at a high dose. It is given orally or through a vein, four times daily, for 7 days or longer. Zidovudine can cause nausea, vomiting, decreased bone marrow function, and decreased blood counts. Combined with valganciclovir, or Valcyte , it is likely to be more toxic to bone marrow. Valganciclovir can cause problems with bone marrow function, leading to low blood counts, sterility, and defects in a fetus. Combined with zidovudine, valganciclovir may cause more toxicity to the bone marrow. It is given twice daily for 7 days or longer. Bortezomib, or Velcade , is given for a few seconds by a rapid push through a needle into the vein. It is given twice weekly for four doses and then stopped for 1 week. Bortezomib can sometimes cause low blood pressure; it also can cause gastrointestinal problems and a low blood platelet count. Rituximab and liposomal doxorubicin are drugs given by a catheter into a vein. Interferon-alpha is given by injection into the skin. Those drugs are not experimental, but their use in Castleman s disease is experimental. Some participants may be treated with a combination of chemotherapy followed by interferon-alpha. Interferon-alpha is infected into the skin by a needle. The natural form of interferon is produced by the body and helps to control viral infections. KSHV decreases the effect of the body s interferon, and the researchers want to see if giving higher doses of interferon will help to control KSHV infection. A positron emission tomography (PET) scan, for research purposes only, may be done up to three times a year. A radioactive sugar molecule called fluorodeoxyglucose, or FDG, is used. It is believed that activated lymphocytes that may be found in participants disease might use more FDG because these cells burn more glucose fuel. This study may or may not have a direct benefit for participants. However, detailed assessments made throughout the study may provide information to help the doctors treat KSHV-MCD better.

Full description

Background: Multicentric Castleman's disease (MCD) is a rare but lethal Kaposi's sarcoma-associated herpesvirus (KSHV) associated lymphoproliferative disorder with a median survival of 2 years. It occurs more often in HIV-infected individuals than those without HIV infection. The poor prognosis is not fully explained by the underlying HIV, as the HIV-negative cases appear to have no survival advantage over the HIV-positive cohort. The disease has no defined standard treatment and has not been prospectively studied in a comprehensive manner. KSHV-MCD may provide a model for the development of targeted oncolytic virotherapy or other pathogenesis-based approaches to viral-associated malignancies. In KSHV-MCD, viral encoded tyrosine kinase genes appear to be possible targets to exploit in a virotherapy approach. Specific viral encoded genes appear to convert zidovudine and ganciclovir (or valganciclovir) into toxic phosphorylated moieties within the KSHV-infected tumor cells, to specifically target the KSHV-infected cells thus leading to specific cell death. If successful, this could have direct therapeutic benefit to participants and also provide a model for further development of this approach in other tumors. Objectives -To study and describe the natural history of KSHV-MCD. Eligibility Age greater than or equal to 18 years Biopsy proven KSHV-associated MCD Design Natural History study Inclusion of treatment as needed, with guidelines for preliminary investigation of a variety of specific treatments of interest High-dose zidovudine and ganciclovir High-dose zidovudine and ganciclovir and bortezomib Sirolimus Rituximab with liposomal doxorubicin followed by interferon-alpha Rituximab with EPOCH chemotherapy

Enrollment

75 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Age greater than or equal to 18 years.

Biopsy proven KSHV-associated MCD, confirmed in the Laboratory of Pathology, CCR.

Willing to give informed consent.

Exclusion criteria

Any abnormality that would be scored as NCI CTC Grade IV toxicity that is unrelated to HIV, its treatment, or to MCD that would preclude protocol treatment and/or observation only.

Presence of another malignancy requiring current treatment that would preclude the use of all of the study treatments or the ability to monitor the natural history of MCD untreated.

Pregnant women are excluded from this study as certain of the study agents have the potential for teratogenic effects

Any condition or set of circumstances that in the opinion of the investigators would make participation in this study unsafe or otherwise inappropriate for a given individual.

Trial design

75 participants in 6 patient groups

Active Treament 3
Active Comparator group
Description:
Patients not responding to high- dose zidovudine and valganciclovir alone may be treated with botezomib plus high- dose zidovudine and valganciclovir
Treatment:
Drug: Zidovudine
Drug: Valganciclovir
Drug: Bortezomib
Active Treatment 1
Active Comparator group
Description:
Single agent sirolimus for patients where targeted oncolytic virotherapy seems suboptimal
Treatment:
Drug: Sirolimus
Active Treatment 2
Active Comparator group
Description:
EPOCH chemotherapy with rituximab may be utilized to rescue such patients, with the intent of stabilizing suchpatients
Treatment:
Drug: Prednisone
Drug: Etoposide
Drug: Doxorubicin
Drug: Cyclophosphamide
Drug: Vincristine
Drug: Filgrastim (G-CSF)
Drug: Rituximab
Active Treatment 4
Active Comparator group
Description:
Rituximab with liposomal doxorubicin (R-Dox) followed by consolidation or lmaintenancel therapy with dose escalating interferon-alpha
Treatment:
Drug: Liposomal Doxorubicin
Drug: Interferon-alpha
Drug: Rituximab
Active Treatment 5
Active Comparator group
Description:
High dose zidovudin and valganciclovir
Treatment:
Drug: Zidovudine
Drug: Valganciclovir
Natural History
Active Comparator group
Description:
Observation Only
Treatment:
Other: Observation Only

Trial contacts and locations

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Data sourced from clinicaltrials.gov

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