Virtual Art Therapy Assisted Re-Integration to Improve Biopsychosocial Outcomes in Adolescent and Young Adult Cancer Survivors, AVATARS Trial

Mayo Clinic

Status: Enrolling

Conditions: Hematopoietic and Lymphatic System Neoplasm; Malignant Solid Neoplasm

Treatments: Procedure: Art Therapy; Other: Survey Administration; Other: Interview

Study type: Interventional

Funder types: Other

Identifiers

NCT07089927

24-012402 (Other Identifier)

AVATARS (Other Identifier)

NCI-2025-04978 (Registry Identifier)

Details and patient eligibility

About

This clinical trial tests the feasibility, usability and acceptability of a virtual art therapy assisted re-integration (AVATARS) intervention to improve biopsychosocial outcomes, such as anxiety, depression, resilience, emotional regulation, stress, and cognition, among adolescent and young adult (AYA) cancer survivors. AYA cancer survivors (especially those treated at adult cancer centers) historically experience worse psychosocial outcomes and lack age appropriate psychosocial support compared to older adult cancer survivors. Creative art therapy accesses the limbic system to provide a corrective emotional experience in response to trauma and can help patients visually express depression, anxiety, and existential fears, process traumatic events, and regain agency and control. The AVATARS intervention may be a feasible, useable and acceptable way to improve biopsychosocial outcomes among AYA cancer survivors.

Full description

PRIMARY OBJECTIVES:

I. Investigate the AVATARS intervention's feasibility, usability, and acceptability among a sample of AYA cancer survivors.

II. Investigate the preliminary efficacy of the AVATARS intervention on biopsychosocial outcomes (i.e. anxiety, depression, resilience, emotional regulation, stress, and cognition) in AYA cancer survivors.

OUTLINE:

Patients complete virtual art therapy sessions, over 60 minutes, every 1-2 weeks, for 4 sessions. Patients then receive a 3D printed replica of their avatar.

After completion of study treatment, patients are followed up at 1 and 4 months.

Enrollment: 20 estimated patients

Sex: All

Ages: 18 to 25 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Aged 18-25 years of age at the time of enrollment and able to provide informed consent
• Mild or greater depression [Patient Health Questionnaire (PHQ-A) score > 5]
• Received a cancer diagnosis during the past year, or completed cancer treatment within the past five years (extended survivorship)
• Have access to an electronic device which supports Zoom videoconferencing (e.g., personal device or public library access)
• Able to read and write in English

Exclusion criteria

• Participation in art therapy within the past 12 months
• Visual or cognitive impairment which may impede completing the art project or the data collection measures
• Endorsed suicidality (via PHQ-A or otherwise)

Trial design

Primary purpose: Supportive Care

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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20 participants in 1 patient group

Supportive care (Virtual art therapy)

Experimental group

Description:

Patients complete virtual art therapy sessions, over 60 minutes, every 1-2 weeks, for 4 sessions. Patients then receive a 3D printed replica of their avatar.

Treatment:

Other: Interview

Other: Survey Administration

Procedure: Art Therapy