Virtual Prism Adaptation Therapy on Hemispatial Neglect

Seoul National University

Status: Terminated

Conditions: Perceptual Disorders; Rehabilitation; Stroke; Recovery of Function; Virtual Reality Exposure Therapy

Treatments: Device: Sham Therapy; Device: Virtual Prism Adaptation Therapy

Study type: Interventional

Funder types: Other

Identifiers

NCT03771872

2018-0154-004

Details and patient eligibility

About

The purpose of this study is to investigate the effect of virtual prism adaptation therapy on hemispatial neglect in chronic stroke patients. This study is the randomized, double-blind, sham-controlled, cross-over design. Total 10 patients will be allocated randomly to either real virtual prism adaptation therapy or sham therapy with the wash-out period of more than 2 weeks. Two sessions (20min/session) per day, for 5days (total 10 sessions) will be provided. Behavioral outcomes will be measured before and after completing a total of 10 sessions therapy.

Enrollment: 2 patients

Sex: All

Ages: 18 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 3 months after stroke onset
• 2 or more tests indicative of hemispatial neglect in following 3 tests: 1)line bisection test, 2)Albert's test, 3)Drawing test.
• Ability to recognize the target object, hand trajectory in the immersive virtual reality
• 16 points or more in the Korean version of mini-mental state examination

Exclusion criteria

• Previous stroke or traumatic brain injury history
• Can not cooperate during the therapy, due to delirium or aphasia
• Unstable medical conditions
• Severe psychiatric symptoms that interfere with the therapy participation (e.g. severe depression, agitation, psychotic symptoms)
• Pregnancy
• Can not maintain sitting posture

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Triple Blind

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2 participants in 2 patient groups

Virtual Prism Adaptation Therapy

Experimental group

Description:

This group will be provided with real virtual prism adaptation therapy. In the real therapy session, the hand trajectory will deviate to the right side in the virtual reality. The deviation angle will be adjusted according to the subject's adaptation. 20min-session will be provided twice a day for 5 days, then the total 10 sessions of therapy will be provided.

Treatment:

Device: Virtual Prism Adaptation Therapy

Sham Therapy

Sham Comparator group

Description:

The therapy is the same as the real virtual prism adaptation therapy, but there will be no deviation of the hand trajectory in the virtual reality.

Treatment:

Device: Sham Therapy