Virtual Reality Cognitive Training for Mild Cognitive Impairment

Changi General Hospital

Status: Completed

Conditions: Mild Cognitive Impairment

Treatments: Behavioral: Active Control; Device: Virtual Reality Cognitive Training

Study type: Interventional

Funder types: Other

Identifiers

NCT06380894

2020/2239

Details and patient eligibility

About

This study aims to assess the feasibility and efficacy of a 10-weekly multi-domain VRCT program on the cognitive function (i.e. attention, memory, and executive functioning) of older adults with MCI.

Full description

This study employed a pilot feasibility parallel design approach. Participants were randomly assigned to either the VRCT intervention group or the active control group. The outcome assessor was blinded. Participants were recruited from outpatient clinics in Changi General Hospital, Singapore. They were referred by treating geriatricians and psycho-geriatricians.

Enrollment: 20 patients

Sex: All

Ages: 65 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• aged 65-85
• diagnosis of MCI by a clinician in accordance to Petersen's criteria
• MMSE ≥ 23
• ability to see and hear
• ability to read and write in either English or Mandarin

Exclusion criteria

• diagnosed with a primary other neurocognitive disorder
• diagnosed with major psychiatric illness such as major depressive disorder or anxiety disorder, severe visual or auditory impairment
• diagnosed with serious medical illnesses including acute or severe asthma, severe or unstable cardiovascular disease, active gastric ulcer, severe liver disease or severe renal disease.

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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20 participants in 2 patient groups

Virtual Reality Cognitive Training

Experimental group

Description:

The program consisted of two components: (1) psychoeducation on cognitive functioning and ways to maintain cognitive health, (2) VR multi-domain cognitive training tasks that target cognitive domains of attention, memory, and executive functioning.

Treatment:

Device: Virtual Reality Cognitive Training

Active Control Group

Active Comparator group

Description:

Participants who were assigned to the active control group were provided treatment-as-usual, which included: (1) psychoeducation on MCI, cognitive functioning, and compensatory strategies, and (2) brain training cognitive stimulation booklet which consisted of weekly homework activities focusing on attention, memory, and executive functioning. Control participants were reviewed for 3 sessions monthly to follow up on their progress on the cognitive stimulation activity booklet.

Treatment:

Behavioral: Active Control