Virtual Reality Exposure and Respiratory Relaxation-Based Coping With Cocaine Craving in Cocaine Users (RVCOC)

Laboratoire de Psychologie des Cognitions

Status: Completed

Conditions: Virtual Reality Exposure Therapy; Cocaine Use Disorder

Treatments: Behavioral: Respiratory Relaxation; Device: Virtual Reality Exposure to Neutral Cues; Device: Virtual Reality Exposure to Cocaine-Related Cues

Study type: Interventional

Funder types: Other

Identifiers

NCT05557149

2021-A00242-39 (Other Identifier)

RVCOC2021

21.02.14.82513 (Other Identifier)

AAC21-SPA-04 (Other Grant/Funding Number)

Details and patient eligibility

About

Our study main objective is to test whether virtual reality exposure could elicit cocaine craving and its physiological arousal in cocaine users. Investigators aim to compare self-reported cocaine craving, self-efficacy to cope with craving and emotional states levels in 11 voluntary and adults cocaine users in 3 consecutive 10-mins conditions: Neutral VR (virtual reality exposure to neutral stimuli), Cocaine VR (virtual reality exposure to cocaine use-related stimuli) and Relaxation (respiratory relaxation).

Enrollment: 11 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Cocaine use within the past 28 days

Exclusion criteria

• Actual manic or hypomanic episode (MINI, Lecrubier and al., 1998)
• Actual psychotic episode (MINI, Lecrubier and al., 1998)
• Actual high suicidal risk (MINI, Lecrubier and al., 1998)
• Being involved in incarceration procedure
• Medical risk for safety while physiological arousal (e.g. cardiac disease)
• Disability for performing virtual reality task (e.g. blindness or deafness)
• Significant motion sickness symptoms (SSQ pre-post total score ≥ 15, Bimberg et al., 2020)

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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11 participants in 3 patient groups

Neutral VR

Sham Comparator group

Description:

Ten minutes virtual reality exposure to neutral stimuli (e.g. neutral picture frames)

Treatment:

Device: Virtual Reality Exposure to Neutral Cues

Cocaine VR

Experimental group

Description:

Ten minutes virtual reality exposure to cocaine use-related stimuli (i.e. peers using cocaine, cocaine paraphernalia, cocaine use preparing, cocaine use, etc.)

Treatment:

Device: Virtual Reality Exposure to Cocaine-Related Cues

Relaxation

Other group

Description:

Ten minutes respiratory relaxation (eyes closed and sitted on a chair)

Treatment:

Behavioral: Respiratory Relaxation