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Viscoelastic Tests-Guided Therapy In Liver Transplantation (VETLT)

H

Hospital Israelita Albert Einstein

Status

Completed

Conditions

Liver Transplant; Complications
Hemostatic Disorder
Bleeding

Treatments

Other: Thromboelastometry-Guided Therapy with Synthetic Factor Concentrates
Other: Usual Care

Study type

Interventional

Funder types

Other

Identifiers

Details and patient eligibility

About

BACKGROUND: Perioperative bleeding and transfusion are important causes of morbidity and mortality in patients undergoing liver transplantation. The aim of this study is to assess whether viscoelastic tests-guided therapy with the use of synthetic factor concentrates impact transfusion rates of hemocomponents in adult patients undergoing liver transplantation.

METHODS: This is an interventional before-after comparative study. Patients undergoing liver transplantation before the implementation of a protocol using thromboelastometry and synthetic factor concentrates were compared to patients after the implementation. Primary outcome was transfusion of any hemocomponents. Secondary outcomes included: transfusion of red blood cells (RBC), fresh frozen plasma (FFP), cryoprecipitate or platelets, clinical complications, length of stay and in-hospital mortality.

Enrollment

237 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Deceased Donor Liver Transplantation
  • Chronic Liver Disease

Exclusion criteria

  • Acute Liver Failure
  • Combined Transplantation
  • Re-Transplantation is Less Than 30 Days After the First Transplant

Trial design

Primary purpose

Treatment

Allocation

Non-Randomized

Interventional model

Sequential Assignment

Masking

None (Open label)

237 participants in 2 patient groups

Usual Care (Before)
Active Comparator group
Description:
No Thromboelastometry No Synthetic Factor Concentrates Usual Care
Treatment:
Other: Usual Care
Thromboelastometry-Guided Therapy (After)
Experimental group
Description:
Thromboelastometry-Guided Therapy with Synthetic Factor Concentrates
Treatment:
Other: Thromboelastometry-Guided Therapy with Synthetic Factor Concentrates

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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