Visfatin Levels Before and After Periodontal Treatment (VL)

Bulent Ecevit University

Status: Completed

Conditions: Periodontal Diseases

Treatments: Procedure: Non-surgical Periodontal Treatment.

Study type: Observational

Funder types: Other

Identifiers

NCT02615626

VLandPT

Details and patient eligibility

About

The purpose of this study was to evaluate visfatin levels in different stages of periodontal diseases and health, moreover the effect of non-surgical periodontal therapy on visfatin levels in Gingival Crevicular Fluid (GCF) and Serum.

Full description

Total of 45 patients were divided into three groups based on their clinical and radiographical examination. Group 1 chronic periodontitis (n: 15), group 2 plaque induced gingivitis (n: 15) and group 3 Periodontal health (n: 15). GCF and serum samples were collected before treatment and 1, 3, 6 months after treatment and were assayed using enzyme linked immunosorbent assay kit.

Enrollment: 45 patients

Sex: All

Ages: 25 to 49 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Group 1 Inclusion Criteria:

• GI>1, PPD≥5mm, CAL≥5mm with alveolar bone loss radiographically.
• Systematically healthy patients

Group 2 Inclusion Criteria:

• No alveolar bone and attachment loss
• Inflammation signs such as redness, edema and increased BOP levels,
• GI≥2, PPD≤3mm, CAL≤3mm.
• Systematically healthy patients

Group 3 Inclusion Criteria:

• No bone and attachment loss,
• GI=0, PPD≤3mm, CAL≤3mm
• Systematically healthy patients

Exclusion Criteria for all groups:

• Aggressive Periodontitis,
• Oral pathologies,
• Patients with any other systemic diseases,
• Pregnant women and those in the lactation period,
• Patients with smoking habit and taking medication
• Patients received periodontal therapy in last 6 months

Trial design

45 participants in 3 patient groups

Group 1

Description:

Periodontal healthy

Treatment:

Procedure: Non-surgical Periodontal Treatment.

Group 2

Description:

Gingivitis, Non-surgical Periodontal Treatment

Treatment:

Procedure: Non-surgical Periodontal Treatment.

Group 3

Description:

Chronic Periodontitis, Non-surgical Periodontal Treatment

Treatment:

Procedure: Non-surgical Periodontal Treatment.