Visual Field Changes and OCT Angiographic Chorioretinal Changes in Patients With Primary Open Angle Glaucoma

Assiut University

Status: Completed

Conditions: Chorioretinal Changes; Visual Field; Primary Open Angle Glaucoma; OCT Angiography

Treatments: Other: Control group; Other: POAG group

Study type: Observational

Funder types: Other

Identifiers

NCT06978101

MD/AZ.AST./OPH026/10/191/1/202

Details and patient eligibility

About

This study aimed to assess the correlation between visual field changes and optical coherence tomography (OCT) angiography changes of retinal nerve fiber layer in patients with primary open angle glaucoma.

Full description

Glaucoma is the leading cause of irreversible blindness worldwide. Since glaucomatous damage is preventable but irreversible, an early diagnosis and close follow-up of glaucoma patients are primordial. Optical coherence tomography angiography (OCTA) is a recently developed, noninvasive imaging modality that detects blood flow through the motion contrast generated by red blood cells.

Currently, there are 2 groups of complementary exams used for the diagnosis and follow-up of glaucoma patients: structural (where OCT has a considerable role) and functional (visual field) optic nerve measurements, Both technologies have strengths and limitations.

A new technology for diagnosis and follow-up that can avoid the limitations summarized above is lacking. OCTA seems to be a good candidate for such a role, OCT can detect the Doppler frequency shift of the backscattered light that provides information on blood flow.

Enrollment: 100 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Primary open angle glaucoma patients.

Exclusion criteria

1. Hazy media.

2. Diabetic Retinopathy.

3. Uveitis.

4. Other Glaucomas

   • Acute congestive glaucoma
   • Secondary glaucomas

Trial design

100 participants in 2 patient groups

POAG group

Description:

Patients had intraocular pressure (IOP)\>21 mmHg,

Treatment:

Other: POAG group

Control group

Description:

Patients without family history of primary open-angle glaucoma (POAG), IOP ˂21mm Hg.

Treatment:

Other: Control group