Visual Function Abnormalities in Strabismus and Amblyopia and Response to Therapy

NeuroTherapia, Inc.

Status: Enrolling

Conditions: Strabismus; Amblyopia

Treatments: Behavioral: Patching therapy, Glasses

Study type: Observational

Funder types: Other

Identifiers

NCT04310241

12-915

Details and patient eligibility

About

Amblyopia and strabismus are characterized by a reduction in visual acuity, contrast sensitivity, grating acuity, vernier acuity, reading difficulties and binocular visual function deficits. Treated patients have residual visual function deficits. The purpose of the current study is to quantify various visual functions in amblyopic and strabismic participants at baseline, during and at the completion of treatment.

Full description

To examine the response of therapy on visual functions in amblyopic and strabismic participants.

The following visual functions will be measured prior to treatment. Eye movements, contrast sensitivity, grating acuity, visual acuity, vernier acuity, binocular visual functions, reading and visual scanning will be measured. The testing will comprise of one or more of the above paradigms depending on participant's cooperation and understanding as majority of the study participants will be children. The above measurements will be repeated during amblyopia therapy ( which comprises of glasses, patching and/or atropine eye drops) and at the completion of treatment. For participants with strabismus requiring strabismus surgery the measurements will be repeated after strabismus surgery.

Enrollment: 150 estimated patients

Sex: All

Ages: 6 months to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• History of amblyopia or presence of amblyogenic risk factors.

Exclusion criteria

• History of neurologic disorders

Trial design

150 participants in 2 patient groups

Control subjects

Description:

Subjects who state they have no eye or neurologic problems or disease other than perhaps wearing glasses or contact lenses and upon review of medical history.

Amblyopia

Description:

Clinical diagnosis of amblyopia

Treatment:

Behavioral: Patching therapy, Glasses