Visual Function in Pediatric Patients With Posterior Lens Opacities

Sun Yat-sen University

Status: Completed

Conditions: Congenital Cataract Polar Posterior

Treatments: Procedure: Phacomulsification lens removal cataract surgery with Intraocular lens(IOL) implantation

Study type: Observational

Funder types: Other

Identifiers

NCT05207007

CCPMOH2020-China20

Details and patient eligibility

About

Prognostic factors determining visual outcomes in patients with posterior polar cataracts and posterior lenticonus are largely unknown. In this trial, the investigators aimed to evaluate the visual outcomes in patients with posterior polar cataracts and posterior lenticonus and try to find out the factors associated with the visual acuity after surgery. Patients enrolled in this study will be followed for at least 6 months and will have study visits at 1 day, 1 week, 1 month, 3 month, 6 month postoperatively.

Full description

Congenital cataract patients have a wide range of presentations of lens opacities with different impact on visual function. Polar cataracts are opacities of the subcapsular cortex in the polar regions of the lens. To our knowledge, anterior polar cataracts are usually visually insignificant, however, even a small posterior lens opacity can impair vision because of their close proximity to the macula. Visual impairment could be caused by an opacity that blocks the visual axis, refractive error, posterior lesion-induced optical distortion, or amblyopia. Therefore, surgery is often recommended when visual function is significantly affected. The primary indication for surgical intervention in cataract is poor visual acuity. However, the previous studies have shown that preoperative visual acuity is a poor predictor of improvement in the subjectively experienced quality of vision after cataract surgery. Considering the increased risk for capsule rupture during surgery and the sacrifice of accommodation after cataract surgery in eyes with posterior lens opacities, the decision of surgical intervention must be carefully weighed.

In this trial, the investigators aimed to evaluate the changes of visual function, including visual acuity, modulation transfer function, ocular aberrations in the participants with posterior lens opacities. Moreover, various factors which might be associated with postoperative visual acuity were explored. The participants enrolled in this study will be followed for at least 6 months and will have study visits at 1 day, 1 week, 1 month, 3 month, 6 month postoperatively.

Enrollment: 63 patients

Sex: All

Ages: 3 to 14 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Children with posterior polar cataracts or posterior lenticonus who need cataract surgery
• Aged 3-14 years
• Have signed a consent form
• Can be followed

Exclusion criteria

• Have relevant ocular disease other than congenital cataract
• Could not cooperate to the examinations

Trial design

63 participants in 2 patient groups

posterior polar cataracts

Description:

Phacomulsification lens removal cataract surgery with Intraocular lens(IOL) implantation were performed in these patients. Drug: Subconjunctival dexamethasone and general anesthesia All patients received subconjunctival dexamethasone (2 mg) during surgery, and all surgeries were performed under general anesthesia.

Treatment:

Procedure: Phacomulsification lens removal cataract surgery with Intraocular lens(IOL) implantation

posterior lenticonus

Description:

Phacomulsification lens removal cataract surgery with Intraocular lens(IOL) implantation were performed in these patients. Drug: Subconjunctival dexamethasone and general anesthesia All patients received subconjunctival dexamethasone (2 mg) during surgery, and all surgeries were performed under general anesthesia.

Treatment:

Procedure: Phacomulsification lens removal cataract surgery with Intraocular lens(IOL) implantation