Visual Perception in Schizophrenia

University of Rochester

Status

Enrolling

Conditions

Schizophrenia Disorders

Schizo Affective Disorder

Bipolar Disorder

Treatments

Other: EEG measure of visual processing

Study type

Interventional

Funder types

Other

NIH

Identifiers

NCT06911931

R21MH140245 (U.S. NIH Grant/Contract)

STUDY00007500

Details and patient eligibility

About

This study aims to identify novel markers of psychosis using electroencephalography (EEG).

Enrollment

84 estimated patients

Sex

All

Ages

18 to 65 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

All Subjects
Aged 18-65
20/32 visual acuity or better (using in-house optical correction, if necessary)
An ability to speak English well enough to complete study assessments and to consent to the study
Subjects with Schizophrenia-Spectrum Disorder
Meets DSM-5 diagnostic criteria for schizophrenia, schizoaffective disorder, or schizophreniform disorder as confirmed by the Structured Interview for DSM-5 (SCID-5).
Subjects with Bipolar Disorder
Meets DSM-5 diagnostic criteria for bipolar disorder (type I, II, or unspecified) as confirmed by the Structured Interview for DSM-5 (SCID-5).

Exclusion criteria

All subjects
Presence of characteristics that could impair one's ability to comprehend the nature of the study, provide informed consent, or understand the assessment questions, including the following:
- Subject cannot read and understand the instructions well enough to complete the tasks or cannot provide informed consent.
- Intellectual impairment (WRAT-5 score < 70) (at the discretion of experimenter);
- Actively intoxicated, as shown via patient self-report or staff report;
- Substance use disorder in the past 3 months;
- Subject considered high risk for suicidal acts (i.e., active suicidal ideation as determined by clinical interview OR any suicide attempt in 30 days prior to screening);
- Subject violence (involving severe/lethal means or violence occurring in prior 6 months) or extreme agitation.
- Being in a current manic state
- Head injury with loss of consciousness greater than 10 minutes (at the discretion of the experimenter).
- Subject has had electroconvulsive therapy (ECT) in the past 8 weeks;
- Diagnosed with a neurological condition (tumor, stroke, brain injury) or neurological disorder, including seizure disorders. Diagnosed with pervasive developmental disorder (phone screen or medical records)
- Lazy eye or squint or other known ocular pathology
Healthy Control Subjects
Any lifetime psychotic disorder or history of psychiatric hospitalization (self disclosure);
Daily antidepressant, mood stabilizer or antipsychotic medication use in the last 6 months, or benzodiazepine use during the prior 2 days (self-disclosure); iii. First-degree relative(s) with a schizophrenia spectrum disorder (based on subject self-report) or bipolar disorder.
Case-match Control Non-ill Subjects
Any lifetime psychotic disorder (as assessed by SCID/or SSD);
Recurrent depressive episodes or being in a current depressive episode (as assessed by SCID/or SSD)
Persistent threshold psychotic symptoms
History of psychiatric hospitalization;
Daily antidepressant, mood stabilizer or antipsychotic medication use in the last 6 months, or benzodiazepine use during the prior 2 days
First-degree relative(s) with a schizophrenia spectrum disorder (based on subject self-report) or bipolar disorder.
Bipolar Subjects
Persistent threshold psychotic symptoms