Visualization of Carotid Atherosclerosis by 68Ga-MSA

Korea University

Status and phase: Completed; Phase 1

Conditions: Noninvasive Imaging of Atherosclerosis; Carotid Atherosclerosis; Atherosclerosis

Treatments: Other: 68Gallium-MSA

Study type: Interventional

Funder types: Other

Identifiers

NCT01893489

Ga_MSA_CAD_carotid

Details and patient eligibility

About

Until now, no specific atherosclerosis-targeting agent labeled with positron emitter is not yet available. Investigators developed neomannosyl human serum albumin(MSA) for the terminal mannose residues of MSA binding with the mannose receptors of macrophages in atherosclerosis, and investigators investigate whether 68Ga-MSA can be a novel agent for non-invasive molecular imaging of carotid atherosclerotic lesion in PET.

Enrollment: 12 patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• •coronary artery disease patients with carotid plaques

  • control without carotid plaque

Exclusion criteria

• •pregnancy, allergy to albumin, any acute or chronic inflammatory disease, hematologic disease, liver disease, renal disease

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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12 participants in 2 patient groups

Atherosclerosis

Active Comparator group

Description:

coronary artery disease patients with carotid plaques confirmed by a ultrasound study

Treatment:

Other: 68Gallium-MSA

control

Sham Comparator group

Description:

no coronary artery disease patients without carotid plaques confirmed by a ultrasound study

Treatment:

Other: 68Gallium-MSA