Visuospatial and Affective Abilities in Parkinson Disease

IRCCS Centro Neurolesi "Bonino-Pulejo"

Status: Not yet enrolling

Conditions: Alexithymia; Visuospatial/Perceptual Abilities; Parkinson Disease

Treatments: Other: Prismatic adaptation

Study type: Interventional

Funder types: Other

Identifiers

NCT06341829

PRISM1

Details and patient eligibility

About

The aim of the study is to investigate whether prismatic adaptation (AP), a non-invasive neuromodulation technique, that involves the use of lenses that deviate the visual field, can modulate alexithyima and performance in visuospatial tasks in patients with Parkinson disease. Furthermore, brain activity during the prismatic adaptation and post-adaptation phases will be recorded using functional near-infrared spectroscopy (fNIRS) and high-density electroencephalography (HD-EEG).

Enrollment: 63 estimated patients

Sex: All

Ages: 18 to 90 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Over 18 years old;
• Right-handed;
• Diagnosis of idiopathic Parkinson's disease according to the UK Brain Bank criteria (Lyon and Pahwa, 2011);
• Hoehn and Yahr Stadium (Hoehn and Yahr, 1996) <2,5;
• Stable pharmacological treatment (dopaminergic therapy: dopamine agonists and Levo-dopa) in the last 6 weeks.

Exclusion criteria

• • Sensory-motor deficits that can hinder neuropsychological assessment;
• Visual system disorders (blindness, glaucoma);
• Atypical parkinsonisms;
• PD with dementia according to the criteria of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) (American Psychiatric Association).

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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63 participants in 3 patient groups

Right prismatic adaptation

Experimental group

Description:

This group will undergo right prismatic adaptation

Treatment:

Other: Prismatic adaptation

Left prismatic adaptation

Experimental group

Description:

This group will undergo left prismatic adaptation

Treatment:

Other: Prismatic adaptation

Neutral prismatic adaptation

Sham Comparator group

Description:

This group will undergo neutral lenses

Treatment:

Other: Prismatic adaptation