Vitamin A and D Intake in Pregnancy, Infant Supplementation and Asthma Development

Norwegian Institute of Public Health

Status: Completed

Conditions: Asthma in Children

Treatments: Other: Maternal vitamin A and D intake during pregnancy

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT03197233

221097

ZO1ES49019 (Other Grant/Funding Number)

PDB532_journal 08/2602-29

Details and patient eligibility

About

The objective of this study is to investigate if maternal intake of vitamins A and D from food and dietary supplements during pregnancy, and infant supplementation with these vitamins, are associated with development of asthma in the offspring.

Full description

This study was conducted as part of the research project "Causal pathways for asthma" funded by the Norwegian Research Council (2013-2017). The overall objective was to study if different pregnancy and early life exposures affect the risk of asthma and allergic diseases in children, and if these exposures exert their effects through epigenetic mechanisms, more specifically DNA methylation.

For this project, including the current study, existing data from the Norwegian Mother and Child Study (MoBa file version 9, 115 398 children and 95 248 mothers) were linked with the Medical Birth Registry of Norway and the Norwegian Prescription Database. The MoBa study recruited pregnant women between 1999 and 2008, at approximately 18 weeks of gestation. Beginning 2002, women completed a food frequency questionnaire about dietary intake (food and supplements) in pregnancy. A panel of maternal plasma biomarkers, including plasma retinol and 25-hydroxyvitamin D2 and D3, was available for a random sample of around 3,000 women who gave birth in 2002 and 2003.

Enrollment: 61,676 patients

Sex: All

Ages: 7 to 7 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Available maternal dietary intake data from pregnancy. Child turned 7 years by July 1st 2014.

Exclusion criteria

No maternal baseline questionnaire. Maternal energy intake <4,500 or > 20,000 kJ. No dietary supplement data. No linkage to national birth registry, or non-live births, or multiple births. Child death, or emigration, or unknown vital status.