Vitamin A for BPD Prevention

Sheba Medical Center

Status: Unknown

Conditions: The Relationship Between Oral Vitamin A Administration and the Incidence of BPD in Preterm Infants Born Before Week 29 of Pregnancy

Treatments: Dietary Supplement: Oral Vitamin A

Study type: Interventional

Funder types: Other

Identifiers

NCT04563429

SHEBA-20-7281-LL-CTIL

Details and patient eligibility

About

Chronic bronchopulmonary dysplasia (BPD) is a very common complication in preterm infants born at a young gestational age, and is a serious disease that impairs respiratory long-term outcome and is associated with higher-frequency neurodevelopmental injury. Lowering the incidence of BPD may improve the health of the preterm babies and neurodevelopmental delay of preterm infants.Vitamin A deficiency may be one of the factors associated with the development of BPD in preterm infants. According to the literature, oral vitamin A administration can lower the incidence of BPD. In our study we plan to give 5000 units of retinol / dose / day, every day for 28 days.

Enrollment: 100 estimated patients

Sex: All

Ages: 2 to 5 days old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Premature babies under 29 weeks, at any birth weight
• A preterm baby is less than 4 days to life

Exclusion criteria

• Major congenital malformations
• Known chromosomal disorders

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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100 participants in 2 patient groups

Treatment Group

Experimental group

Treatment:

Dietary Supplement: Oral Vitamin A

Control Group

No Intervention group