Vitamin A Kinetics and Mathematical Modeling in American Women

University of Wisconsin (UW)

Status: Completed

Conditions: Vitamin A Kinetics

Treatments: Other: Vitamin A tracer

Study type: Interventional

Funder types: Other

Identifiers

NCT03248700

A074600 (Other Identifier)

H-2008-0020

AG&LSC/NUTRITIONAL SCI/NUTRITI (Other Identifier)

Details and patient eligibility

About

Women were given a vitamin A tracer, and blood was sampled to determine individual and group vitamin A kinetics. Data were subsequently modeled using compartmental analysis to determine effects of study length on model outcomes.

Full description

This is a longitudinal study in which American women were given an oral, stable isotope tracer of vitamin A, and blood was sampled in a staggered, serial design to determine individual and group vitamin A kinetics. Data were subsequently modeled using compartmental analysis, and study truncation analysis was performed on data to investigate the factor of study duration on resulting vitamin A kinetic models and outputs related to vitamin A metabolism.

Enrollment: 8 patients

Sex: Female

Ages: 19 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• BMI (18.5 - 24.9 kg/m2)

Exclusion criteria

• Smoker
• Pregnant
• Trying to become pregnant
• Lactating
• Weight loss > 4.5 kg during the past 3 months.
• Actively trying to lose weight
• Inability to refrain from drinking alcohol when requested
• Amenorrhea
• Acute or chronic illness including hepatitis
• Current or previous history of anorexia or bulimia
• Concurrent participation in other studies
• Family member already enrolled in the study

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

---

8 participants in 1 patient group

Vitamin A tracer

Experimental group

Description:

A stable isotope tracer of vitamin A was given orally.

Treatment:

Other: Vitamin A tracer